Authors :
Lokhande Vaishnavi; Thorat Suvarna S; Vishal Dokhe
Volume/Issue :
Volume 9 - 2024, Issue 12 - December
Google Scholar :
https://tinyurl.com/59zyrfpv
Scribd :
https://tinyurl.com/3ehe9psr
DOI :
https://doi.org/10.5281/zenodo.14540035
Abstract :
The present study focuses on developing a
tolnaftate emulgel to enhance topical delivery and
minimize side effects through targeted application.
Utilizing an emulgel method, tolnaftate was formulated
with various excipients, including Carbopol 934, propylene
glycol, and clove oil as a natural penetration enhancer at
different concentrations (1-5% w/w). Comprehensive
evaluations were conducted, assessing parameters such as
rheology, pH, drug content, skin irritation, washability,
drug release, swelling index, antifungal activity against
Candida albicans, and stability. Notably, formulation F2
achieved a remarkable 97.45% in vitro drug release within
8 hours and maintained stability over 3 months without
significant changes. Skin irritation tests confirmed its
safety, while its antifungal efficacy exceeded that of the
pure drug and commercial tolnaftate creams. These
findings suggest that the tolnaftate emulgel, particularly
formulation F2, offers a promising strategy for improved
topical delivery, combining enhanced penetration,
stability, and antifungal activity.
Keywords :
Tolnaftate, Emulgel, Topical Delivery, Penetration Enhancer, Candida Albicans.
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The present study focuses on developing a
tolnaftate emulgel to enhance topical delivery and
minimize side effects through targeted application.
Utilizing an emulgel method, tolnaftate was formulated
with various excipients, including Carbopol 934, propylene
glycol, and clove oil as a natural penetration enhancer at
different concentrations (1-5% w/w). Comprehensive
evaluations were conducted, assessing parameters such as
rheology, pH, drug content, skin irritation, washability,
drug release, swelling index, antifungal activity against
Candida albicans, and stability. Notably, formulation F2
achieved a remarkable 97.45% in vitro drug release within
8 hours and maintained stability over 3 months without
significant changes. Skin irritation tests confirmed its
safety, while its antifungal efficacy exceeded that of the
pure drug and commercial tolnaftate creams. These
findings suggest that the tolnaftate emulgel, particularly
formulation F2, offers a promising strategy for improved
topical delivery, combining enhanced penetration,
stability, and antifungal activity.
Keywords :
Tolnaftate, Emulgel, Topical Delivery, Penetration Enhancer, Candida Albicans.