Formulation And Evaluation of Salicylic Acid / Sodium Salicylate Topical Gels Using Peg Polymers

Authors : Terli Bhargavi Punyayathi

Volume/Issue : Volume 7 - 2022, Issue 12 - December

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Topical gels have advantages in the formulation to circumvent the first pass effect, to improve its bio availability, to reduce dosing frequency and dose related side effects. Sodium salicylate and salicylic acid are formulated as topical gels which is used as the keratolytic or anti-inflammatory agent. Topical gels of salicylic acid is a BCS class I drug were prepared by fusion method and characterized by testing for clarity, homogenesity, spreadibility, melting point, freezing point, surface pH, drug content uniformity and in-vitro drug dissolution studies. Nine formulations of salicylic acid and sodium salicylate topical gels are formulated at different ratios of polymers like poly ethylene glycols 400 and 4000 and evaluated.

Keywords : Salicylic Acid, Sodium Salicylate, Transdermal Gel, In-Vitro Drug Release Kinetic Studies, BCS Class I Drug.


Paper Submission Last Date
31 - March - 2023

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