Authors :
Anurag Srivastava; Sangeeta Singh; Aswani Kumar
Volume/Issue :
Volume 6 - 2021, Issue 12 - December
Google Scholar :
http://bitly.ws/gu88
Scribd :
https://bit.ly/3eiPOPN
Abstract :
Onychomycosis is a fungus that infects the
human nail and affects 19% of the world's population. It
is responsible for half of all nail problems in diabetic and
older individuals. Dermatophytes are the most frequent
cause of onychomycosis, although yeasts and candida may
also cause it, because the illness is persistent, difficult to
eliminate, and prone to recurrence, it is tough to control.
The diseased nails are unsightly, discoloured, thicker, and
dystrophic, which has a detrimental effect on the patient's
social life.
Topical therapy has been shown to be a viable
alternative to systemic administration in the treatment of
onychomycosis, since it is capable of overcoming many of
the constraints of systemic administration and targeting
the medication at its site of action with minimal
interactions and side effects. Limited permeability of the
medication through the nail plate and blood supply in the
afflicted region may result in sub-therapeutic
concentrations, which may be addressed by applying the
drug topically. Furthermore, since most commonly used
formulations are easily removed by rubbing or washing,
they are not particularly suited to the nail. To get over
these obstacles, ungual delivery (drug administration
across the nail plate) may be used.
Transungual drug delivery is a method for
transporting drugs through the nail to provide targeted
medication administration in the treatment of nail
disorders. “Trans” means “through”, and “unguis”
means “nails” in the word transungual [10]. Because of its
superior adherence and localised action, which offers less
systemic adverse effects, the transungual medication
delivery method is considered to be highly useful in
managing nail diseases.
Nail lacquers seem to be commercially preferred for
a variety of reasons, including their long residence
duration on the nail plate and low wash-off or loss
resistance. Nail lacquers are also generally accepted by
patients and simple to apply, in addition to preventing
tranonychial water loss and allowing for prolonged
medication diffusion through concentration gradients.
Onychomycosis is a fungus that infects the
human nail and affects 19% of the world's population. It
is responsible for half of all nail problems in diabetic and
older individuals. Dermatophytes are the most frequent
cause of onychomycosis, although yeasts and candida may
also cause it, because the illness is persistent, difficult to
eliminate, and prone to recurrence, it is tough to control.
The diseased nails are unsightly, discoloured, thicker, and
dystrophic, which has a detrimental effect on the patient's
social life.
Topical therapy has been shown to be a viable
alternative to systemic administration in the treatment of
onychomycosis, since it is capable of overcoming many of
the constraints of systemic administration and targeting
the medication at its site of action with minimal
interactions and side effects. Limited permeability of the
medication through the nail plate and blood supply in the
afflicted region may result in sub-therapeutic
concentrations, which may be addressed by applying the
drug topically. Furthermore, since most commonly used
formulations are easily removed by rubbing or washing,
they are not particularly suited to the nail. To get over
these obstacles, ungual delivery (drug administration
across the nail plate) may be used.
Transungual drug delivery is a method for
transporting drugs through the nail to provide targeted
medication administration in the treatment of nail
disorders. “Trans” means “through”, and “unguis”
means “nails” in the word transungual [10]. Because of its
superior adherence and localised action, which offers less
systemic adverse effects, the transungual medication
delivery method is considered to be highly useful in
managing nail diseases.
Nail lacquers seem to be commercially preferred for
a variety of reasons, including their long residence
duration on the nail plate and low wash-off or loss
resistance. Nail lacquers are also generally accepted by
patients and simple to apply, in addition to preventing
tranonychial water loss and allowing for prolonged
medication diffusion through concentration gradients.
