Formulation and Evaluation of Metronidazole Mucoadhesive Vaginal Tablets

Authors : S. A. Chore, Dr. A. L. Chore

Volume/Issue : Volume 5 - 2020, Issue 3 - March

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Vaginitis is a very common gynecological problem in women of all age groups. There are three types of infectious vaginitis: candidiasis, trichomoniasis, and bacterial vaginosis. Vaginitis can be caused by single or mixed vaginal infections. Approximately 30% of women suffering from vaginitis problem. The present study is to formulate and evaluate mucoadhesive tablet, this will increase the residence time at the site of the absorption also it associate with the self-cleansing action of vaginal tract. These results indicate that metronidazole containing vaginal mucoadhesive systems can be further developed for safe, convenient, and effective treatment of vaginal candidiasis with required dose frequency. A new emerging system is proposed for improving the sustained release of formulation and their combination using different polymers, such as, HPMC K-100M, Polyethylene oxide WSR-303, Xanthum gum and Grantrez. All polymer and their combination with different concentration blends with drug were with poor flow properties and compressibility. Hence, wet granulation method with PVP K 30 as binder was used for further tableting were tried in order to get desired sustained release of drug over of 8 hrs. All the formulations were evaluated % drug content, in vitro drug release, % water uptake study, IR spectrum and mucoadhesive strength. The tablets with 10% w/w of polymer showed a good sustained release over a period of 8h. It was found that, as the polymer concentration was increased, the drug release decreased. The drug release from HPMC K100: Polyox WSR-303(1:1) tablet (F15) was found to be 90.93±0.23% after 8 hrs of dissolution using USP (XXIII) dissolution apparatus II (DT 60, Veego Instruments).

Keywords : Mucoadhesive, Metronidazole, HPMC K-100 M, Polyethylene oxide WSR-303, Xanthum gum, Grantrez.


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