Authors :
S. A. Chore, Dr. A. L. Chore
Volume/Issue :
Volume 5 - 2020, Issue 3 - March
Google Scholar :
https://goo.gl/DF9R4u
Scribd :
https://bit.ly/3cnNljT
Abstract :
Vaginitis is a very common gynecological
problem in women of all age groups. There are three
types of infectious vaginitis: candidiasis, trichomoniasis,
and bacterial vaginosis. Vaginitis can be caused by
single or mixed vaginal infections. Approximately 30%
of women suffering from vaginitis problem. The present
study is to formulate and evaluate mucoadhesive tablet,
this will increase the residence time at the site of the
absorption also it associate with the self-cleansing action
of vaginal tract. These results indicate that
metronidazole containing vaginal mucoadhesive systems
can be further developed for safe, convenient, and
effective treatment of vaginal candidiasis with required
dose frequency. A new emerging system is proposed for
improving the sustained release of formulation and
their combination using different polymers, such as,
HPMC K-100M, Polyethylene oxide WSR-303,
Xanthum gum and Grantrez. All polymer and their
combination with different concentration blends with
drug were with poor flow properties and
compressibility. Hence, wet granulation method with
PVP K 30 as binder was used for further tableting were
tried in order to get desired sustained release of drug
over of 8 hrs. All the formulations were evaluated %
drug content, in vitro drug release, % water uptake
study, IR spectrum and mucoadhesive strength. The
tablets with 10% w/w of polymer showed a good
sustained release over a period of 8h. It was found that,
as the polymer concentration was increased, the drug
release decreased. The drug release from HPMC K100: Polyox WSR-303(1:1) tablet (F15) was found to be
90.93±0.23% after 8 hrs of dissolution using USP
(XXIII) dissolution apparatus II (DT 60, Veego
Instruments).
Keywords :
Mucoadhesive, Metronidazole, HPMC K-100 M, Polyethylene oxide WSR-303, Xanthum gum, Grantrez.
Vaginitis is a very common gynecological
problem in women of all age groups. There are three
types of infectious vaginitis: candidiasis, trichomoniasis,
and bacterial vaginosis. Vaginitis can be caused by
single or mixed vaginal infections. Approximately 30%
of women suffering from vaginitis problem. The present
study is to formulate and evaluate mucoadhesive tablet,
this will increase the residence time at the site of the
absorption also it associate with the self-cleansing action
of vaginal tract. These results indicate that
metronidazole containing vaginal mucoadhesive systems
can be further developed for safe, convenient, and
effective treatment of vaginal candidiasis with required
dose frequency. A new emerging system is proposed for
improving the sustained release of formulation and
their combination using different polymers, such as,
HPMC K-100M, Polyethylene oxide WSR-303,
Xanthum gum and Grantrez. All polymer and their
combination with different concentration blends with
drug were with poor flow properties and
compressibility. Hence, wet granulation method with
PVP K 30 as binder was used for further tableting were
tried in order to get desired sustained release of drug
over of 8 hrs. All the formulations were evaluated %
drug content, in vitro drug release, % water uptake
study, IR spectrum and mucoadhesive strength. The
tablets with 10% w/w of polymer showed a good
sustained release over a period of 8h. It was found that,
as the polymer concentration was increased, the drug
release decreased. The drug release from HPMC K100: Polyox WSR-303(1:1) tablet (F15) was found to be
90.93±0.23% after 8 hrs of dissolution using USP
(XXIII) dissolution apparatus II (DT 60, Veego
Instruments).
Keywords :
Mucoadhesive, Metronidazole, HPMC K-100 M, Polyethylene oxide WSR-303, Xanthum gum, Grantrez.
