Authors :
S.Janani; S.P.Senthil; R.Senthamarai
Volume/Issue :
Volume 7 - 2022, Issue 5 - May
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3QrUbKc
DOI :
https://doi.org/10.5281/zenodo.6655177
Abstract :
The main purpose of the research is to
develop and evaluate a dental gel containing a herbal
medicine for the management of toothache. The
ethanolic extract of aerial root of Ficus benghalensis was
prepared and it was evaluated for organoleptice
properties, pH and phytochemical screening.
Antimicrobial activity of the extract was done against
streptococcus mutans using well diffusion method. The
gel was prepared using Carbopol, propylene glycol and
clove oil as a permeation enhancer. Six gel formulations
were prepared at two different grades and various
concentration of Carbopol. The formulations were
evaluated for different parameters such as appearance,
pH, viscosity, spreadability. Theoptimizedbatchwas
subjected to further studies via. drug content, stability
testing, diffusion study to determine percent cumulative
release of drug from gel formulations and antimicrobial
study. From the antimicrobial study, it was observed the
optimized formulation and marketed formulation
produced almost equal zone of inhibition. The evaluation
parameters of optimized batch indicate that the
prepared dental gel is stable, good drug delivery system
and contains antimicrobial agents for the prevention of
dental caries and management of tooth ache.
Keywords :
Aerial root, Ficus benghalensis, clove oil, dental gel, Carbopol
The main purpose of the research is to
develop and evaluate a dental gel containing a herbal
medicine for the management of toothache. The
ethanolic extract of aerial root of Ficus benghalensis was
prepared and it was evaluated for organoleptice
properties, pH and phytochemical screening.
Antimicrobial activity of the extract was done against
streptococcus mutans using well diffusion method. The
gel was prepared using Carbopol, propylene glycol and
clove oil as a permeation enhancer. Six gel formulations
were prepared at two different grades and various
concentration of Carbopol. The formulations were
evaluated for different parameters such as appearance,
pH, viscosity, spreadability. Theoptimizedbatchwas
subjected to further studies via. drug content, stability
testing, diffusion study to determine percent cumulative
release of drug from gel formulations and antimicrobial
study. From the antimicrobial study, it was observed the
optimized formulation and marketed formulation
produced almost equal zone of inhibition. The evaluation
parameters of optimized batch indicate that the
prepared dental gel is stable, good drug delivery system
and contains antimicrobial agents for the prevention of
dental caries and management of tooth ache.
Keywords :
Aerial root, Ficus benghalensis, clove oil, dental gel, Carbopol
