Numerous natural ingredients are antimicrobial and antifungal. These characteristics must be compatible with the pathogens to be eradicated. Environmental factors and oral biology imbalances influence the development of the commensal oral cavity. Numerous plant extracts may contribute to maintaining a healthy commensal balance. Measuring the biotolerant properties of plant extracts is essential for determining the antibacterial and fungal properties of the extracts and maintaining the pathogen balance by preventing bacteria from becoming virulent. The biotolerance of plant extracts is determined using the biomass index, Temperature and pH changes, biostability, absorption and residual capacity, and pathogen opsonization. This study aims to establish the optimal concentration for future research trials; additionally, it will serve as a reference for measuring the development of oral commensals during the pathogenesis of dental and oral mucosa infections. The study was evaluated as a bio-tolerance concept to plant extracts as regulators of the oral commensal balance.

Keywords : Formula inhibition, Oral commensals, Plant extracts