Authors :
Jagadish Chandra Sharma; Ramesh Chandra; Meena S Deogade; Arvind Duhan; Vikram Sharma; Subendu Sarkar
Volume/Issue :
Volume 10 - 2025, Issue 7 - July
Google Scholar :
https://tinyurl.com/3846k4dj
Scribd :
https://tinyurl.com/4v9r8erd
DOI :
https://doi.org/10.38124/ijisrt/25jul1925
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Note : Google Scholar may take 30 to 40 days to display the article.
Abstract :
Delivery via cesarean section (C-section) heightens the likelihood of surgical site infection (SSI). Expensive
medications and dressings are employed to manage the healing of C-section wounds, which may lead to a delayed healing
process and an extended hospital stay. Consequently, complementary therapies and alternative medicines have recently
become more popular. In this context, various studies indicate that the topical application of honey dressing is beneficial for
the rapid recovery of C-section wounds in mothers. This paper aims to explore the potential roles of honey in the healing of
C-section wounds. Studies were selected by searching for keywords such as honey, cesarean section, C-section, surgical site
infection (SSI), wound healing, and tissue remodelling. Research articles, case studies, clinical trials, and reviews were
obtained from databases including PubMed, Web of Science, Google Scholar, Embase, Medline, and Scopus. Only full
articles published in English up to June 2025 were included in this study. Data gathered from various sources indicates that
honey is an easily accessible, cost-effective natural product, abundant in a wide range of nutritional components. Honey
possesses numerous medicinal properties. It reduces inflammation, oxidative stress, microbial infections, and scar formation.
Nutritionally rich honey promotes wound healing by enhancing cell proliferation and migration, angiogenesis through the
elevation of growth factors, as well as tissue remodelling via collagen degradation. Moreover, the viscosity and hygroscopic
characteristics of honey safeguard wounds against infection and dehydration. The use of honey dressing leads to a faster
recovery from post-cesarean wound and SSI when compared to the conventional treatment strategies.
Keywords :
Cesarean Section; C-section; Honey; Surgical Site Infection (SSI), Wound Healing.
References :
- Mascarello KC, Horta BL, Silveira MF. Maternal complications and cesarean section without indication: systematic review and meta-analysis. Rev Saude Publica 2017;51:105.
- Baklola M, Terra M, Elsehrawy MG, Alali H, Aljohani SS, Alomireeni AA, et al. Epidemiology of surgical site infections post-cesarean section in Africa: a comprehensive systematic review and meta-analysis. BMC Pregnancy Childbirth. 2025;25:465.
- Alshahrani NZ, Albeshry AM, Aljunaid MA, Kilani MA. Prevalence of surgical site infections post-cesarean section in Saudi Arabia: A systematic review and meta-analysis. J Infect Public Health 2025;18:102855.
- Nilawati Usman A, Sartini S, Yulianti R, Kamsurya M, Oktaviana A, Nulandari Z, et al. Turmeric extract gel and honey in post-cesarean section wound healing: A preliminary study. F1000Res. 2024;12:1095.
- Hanacek J, Vojtech J, Urbankova I, Krcmar M, Křepelka P, Feyereisl J, et al. Ultrasound cesarean scar assessment one year postpartum in relation to one- or two-layer uterine suture closure. Acta Obstet Gynecol Scand 2020;99:69-78.
- Kawakita T, Landy HJ. Surgical site infections after cesarean delivery: epidemiology, prevention and treatment. Matern Health Neonatol Perinatol 2017;3:12.
- Sibomana O, Bugenimana A, Oke GI, Egide N. Prevalence of post-caesarean section surgical site infections in Rwanda: A systematic review and meta-analysis. Int Wound J 2024;21:e14929.
- Niazi A, Moradi M, Askari VR, Sharifi N. Effect of complementary medicine on pain relief and wound healing after cesarean section: A systematic review. J Pharmacopuncture 2021;24:41-53.
- Vandamme L, Heyneman A, Hoeksema H, Verbelen J, Monstrey S. Honey in modern wound care: a systematic review. Burns. 2013;39:1514-25.
- Squadrone S, Brizio P, Stella C, Pederiva S, Brusa F, Mogliotti P, et al. Trace and rare earth elements in monofloral and multifloral honeys from Northwestern Italy; A first attempt of characterization by a multi-elemental profile. J Trace Elem Med Biol 2020;61:126556.
- Mureșan CI, Cornea-Cipcigan M, Suharoschi R, Erler S, Mărgăoan R. Honey botanical origin and honey-specific protein pattern: Characterization of some European honeys. LWT 2022;154:112883.
- Khan SU, Anjum SI, Rahman K, Ansari MJ, Khan WU, Kamal S, et al. Honey: Single food stuff comprises many drugs. Saudi J Biol Sci 2018;25:320-5.
- Puvaca N, Bursic V, Brkic I, Tankosic JV, Prodanovic R, Vukovic G, et al. Toxicological assessment of honey from conventional and organic production and risk assessment for public health. J Cent Eur Agric 2024;25:554-66.
- Er Demirhan B, Demirhan B. Detection of antibiotic residues in blossom honeys from different regions in Turkey by LC-MS/MS method. Antibiotics (Basel). 2022;11:357.
- Yan S, Wang K, Naggar YA, Heyden YV, Zhao L, Wu L, et al. Natural plant toxins in honey: An ignored threat to human health. J Hazard Mater 2022;424:127682.
- Islam MN, Khalil MI, Islam MA, Gan SH. Toxic compounds in honey. J Appl Toxicol 2014;34:733-42.
- Hermanns R, Mateescu C, Thrasyvoulou A, Tananaki C, Wagener FADTG, Cremers NAJ. Defining the standards for medical grade honey. J Apic Res 2019;59,125-35.
- Postmes T, van den Bogaard AE, Hazen M. The sterilization of honey with cobalt 60 gamma radiation: a study of honey spiked with spores of Clostridium botulinum and Bacillus subtilis. Experientia 1995;51:986-9.
- Mehrabian AR. Medical grade of honey: Ecology of production, botanical origin, authenticity and safety. 2024. http://doi.org/10.5772/intechopen.1007158.
- Eteraf-Oskouei T, Najafi M. Traditional and modern uses of natural honey in human diseases: a review. Iran J Basic Med Sci 2013;16:731-42.
- Tashkandi H. Honey in wound healing: An updated review. Open Life Sci 2021;16:1091-1100.
- Pleeging CCF, Wagener FADTG, de Rooster H, Cremers NAJ. Revolutionizing non-conventional wound healing using honey by simultaneously targeting multiple molecular mechanisms. Drug Resist Updat 2022;62:100834.
- Majid E, Pathan S, Zuberi BF, Rehman M, Malik S. Comparison of honey & povidone iodine dressings in post-cesarean surgical site wound infection healing. Pak J Med Sci 2023;39:1803-8.
- Ngonzi J, Ssenkumba B, Nambogo N, Ssedyabane F, Kamugisha A, Nkwangu D, et al. Outcomes of a honey and olive oil-based dressing material on wounds of women that have had a caesarean section in south-western Uganda. Int Wound J 2024;21:e70038.
- Udwadia TE. Ghee and honey dressing for infected wounds. Indian J Surg 2011;73:278-83.
- Al-Waili NS, Saloom KY. Effects of topical honey on post-operative wound infections due to gram positive and gram negative bacteria following caesarean sections and hysterectomies. Eur J Med Res 1999;4:126-30.
- Nikpour M, Shirvani MA, Azadbakht M, Zanjani R, Mousavi E. The effect of honey gel on abdominal wound healing in cesarean section: a triple blind randomized clinical trial. Oman Med J 2014;29:255-9.
- Bocoum A, Riel SJJMV, Traore SO, Ngo Oum Ii EF, Traore Y, Thera AT, et al. Medical-grade honey enhances the healing of caesarean section wounds and is similarly effective to antibiotics combined with povidone-iodine in the prevention of infections-a prospective cohort study. Antibiotics (Basel) 2023;12:92.
- Rohmatin E, Patmawati NM, Yuliastuti S, Sahlan M. Topical effect of Tetragonula sapiens honey on the healing process of post-caesarean section wounds. Int J Appl Pharm 2022;14:18-21.
- Nikpour M, Delavar MA, Khafri S, Ghanbarpour A, Moghadamnia AA, Esmaeilzadeh S, et al. The use of honey and curcumin for episiotomy pain relief and wound healing: A three-group double-blind randomized clinical trial. Nurs Midwifery Stud 2019;8:64-9.
- Sharma JC, Chandra R, Erra AK, Bhandari V, Malik S, Singh A, et al. Use of medical grade honey for management of surgical site infection. World J Pharm Res 2024;13:756-63.
- Surya R, Manurung ES, Saroyo YB, Irwinda R, Banamtuan RA, Boru CY, et al. Management of abdominal wound dehiscence following cesarean section in district area of Indonesia: Honey as an alternative dressing. JSAFOG 2023;15: 472-474.
- Ranneh Y, Akim AM, Hamid HA, Khazaai H, Fadel A, Zakaria ZA, et al. Honey and its nutritional and anti-inflammatory value. BMC Complement Med Ther 2021;21:30.
- Ahmed S, Sulaiman SA, Baig AA, Ibrahim M, Liaqat S, Fatima S, et al. Honey as a potential natural antioxidant medicine: an insight into its molecular mechanisms of action. Oxid Med Cell Longev 2018;2018:8367846.
- Majtan J, Kumar P, Majtan T, Walls AF, Klaudiny J. Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Exp Dermatol 2010;19:e73-9.
- Ogwu MC, Izah SC. Honey as a natural antimicrobial. antibiotics (Basel). 2025;14:255.
- Nolan VC, Harrison J, Wright JEE, Cox JAG. Clinical significance of manuka and medical-grade honey for antibiotic-resistant infections: A systematic review. Antibiotics (Basel) 2020;9:766.
Delivery via cesarean section (C-section) heightens the likelihood of surgical site infection (SSI). Expensive
medications and dressings are employed to manage the healing of C-section wounds, which may lead to a delayed healing
process and an extended hospital stay. Consequently, complementary therapies and alternative medicines have recently
become more popular. In this context, various studies indicate that the topical application of honey dressing is beneficial for
the rapid recovery of C-section wounds in mothers. This paper aims to explore the potential roles of honey in the healing of
C-section wounds. Studies were selected by searching for keywords such as honey, cesarean section, C-section, surgical site
infection (SSI), wound healing, and tissue remodelling. Research articles, case studies, clinical trials, and reviews were
obtained from databases including PubMed, Web of Science, Google Scholar, Embase, Medline, and Scopus. Only full
articles published in English up to June 2025 were included in this study. Data gathered from various sources indicates that
honey is an easily accessible, cost-effective natural product, abundant in a wide range of nutritional components. Honey
possesses numerous medicinal properties. It reduces inflammation, oxidative stress, microbial infections, and scar formation.
Nutritionally rich honey promotes wound healing by enhancing cell proliferation and migration, angiogenesis through the
elevation of growth factors, as well as tissue remodelling via collagen degradation. Moreover, the viscosity and hygroscopic
characteristics of honey safeguard wounds against infection and dehydration. The use of honey dressing leads to a faster
recovery from post-cesarean wound and SSI when compared to the conventional treatment strategies.
Keywords :
Cesarean Section; C-section; Honey; Surgical Site Infection (SSI), Wound Healing.