Authors :
Hamza Oualhadj; Fatima Ezzahra Bouanani; Saliha Chellak; Abderrahmane Boukhira
Volume/Issue :
Volume 9 - 2024, Issue 5 - May
Google Scholar :
https://tinyurl.com/29kax9bz
Scribd :
https://tinyurl.com/3spa3eke
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24MAY2229
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Bisalbuminemia, characterised by the division
of the albumin fraction on serum protein electrophoresis
without an increase in concentration, is a rare protein
anomaly that can present as either congenital or acquired.
While congenital bisalbuminemia has a genetic basis,
acquired bisalbuminemia is often associated with various
underlying conditions, including excessive use of beta-
lactam antibiotics, pancreatic fistula, and certain
monoclonal immunoglobulins.
Recent interest has emerged regarding the potential
relationship between bisalbuminemia and diabetes
mellitus. This study aims to explore the role of diabetes in
acquired bisalbuminemia through the presentation of two
cases and a review of relevant literature.
Case 1 describes a 68-year-old female with recurrent
pneumorespiratory infections, leading to the discovery of
bisalbuminemia and subsequent diagnosis of diabetes
mellitus. Case 2 involves a 71-year-old patient presenting
with worsening lower back pain and bisalbuminemia,
ultimately leading to a diagnosis of diabetes mellitus.
Discussion highlights the significance of diabetes as
a potential contributing factor to acquired
bisalbuminemia, as suggested by previous case reports
and prospective studies. While further research with
larger cohorts is needed to confirm these findings, the
inclusion of diabetes biological workup in
bisalbuminemia cases may aid in early detection and
management.
In conclusion, this study underscores the potential
association between uncontrolled diabetes and acquired
bisalbuminemia, suggesting the importance of assessing
for diabetes in such cases to improve diagnostic
approaches for this rare condition.
References :
- Agarwal P, Parkash A, Tejwani N, Mehta A. Bisalbuminemia: A Rare Finding on Serum Electrophoresis. Indian Journal of Hematology and Blood Transfusion. 2018 Jul 1;34(3):558–9.
- Valasek MA, Hopley RT, Wians FH. Resolving the baneful and banal: Bisalbuminemia in an adult with Waldenström macroglobulinemia. Lab Med. 2008;39(12):723–6.
- Kapatia G, Wadhwa M, Malhotra P, Prakash G, Aggarwal R. Bisalbuminemia: A Pathologist’s Insight of an Uncommon Phenomenon. J Lab Physicians. 2021 Sep;13(03):219–23.
- Vladutiu AO. Bisalbuminemia and Diabetes? JAMA [Internet]. 1976 Nov 22;236(21):2393. Available from: https://doi.org/10.1001/jama.1976.03270220015015
- Lugat A, Caillon H, Chaillous L, Cariou B, Drui D. Severely uncontrolled diabetes: a new aetiology of acquired bisalbuminaemia. Vol. 46, Diabetes and Metabolism. Elsevier Masson SAS; 2020. p. 341–2.
- Shetty JK, Maradi R, Prabhu K, Bhat G. Bisalbuminemia in a hypothyroid patient with diabetes: A case report. Journal of Clinical and Diagnostic Research. 2015 Sep 1;9(9).
- Chachi EM, Bouabdellah M, Clinique C, Biochimie /, Cas B, Biochimie Bisalbuminémie C/, et al. La bisalbuminémie : à propos de trois cas. revue de biologie médicale [Internet]. 2023;376. Available from: https://www.researchgate.net/publication/376232689
- Swain B, Otta S. Streptococcus mitis: An Unusual Causative Agent for Urinary Tract Infection. J Lab Physicians. 2013 Jul;5(02):144–5.
- El Boukhrissi F, Balouch L, Moudden K, Baaj M, Hommadi A, Bamou Y. Bisalbuminémie survenant en dehors des situations habituelles. Revue de Medecine Interne. 2016;37(7):505–6.
- Chhabra S, Bansal F, Saikia B, Minz RW. Bisalbuminemia: a rarely encountered protein anomaly. J Lab Physicians. 2013 Jul;5(02):144–5.
- Lefrère B, Dedôme E, Garcia-Hejl C, Ragot C, Chianea D, Delacour H, et al. Bisalbuminemia: A case report. Revue de Medecine Interne. 2018 Dec 1;39(12):950–4.
- Ghizlane Zoulati, Fatima El Boukhrissi, Ramatou Yèya Maïga, Youssef Bamou, Mohamed El Baaj, Houssine Balouch. A Case of Bisalbuminemia Associated with Nonsteroidal Anti-Inflammatory Drug-Induced Nephrotic Syndrome. Advances in Biochemistry and Biotechnology. 2020.
Bisalbuminemia, characterised by the division
of the albumin fraction on serum protein electrophoresis
without an increase in concentration, is a rare protein
anomaly that can present as either congenital or acquired.
While congenital bisalbuminemia has a genetic basis,
acquired bisalbuminemia is often associated with various
underlying conditions, including excessive use of beta-
lactam antibiotics, pancreatic fistula, and certain
monoclonal immunoglobulins.
Recent interest has emerged regarding the potential
relationship between bisalbuminemia and diabetes
mellitus. This study aims to explore the role of diabetes in
acquired bisalbuminemia through the presentation of two
cases and a review of relevant literature.
Case 1 describes a 68-year-old female with recurrent
pneumorespiratory infections, leading to the discovery of
bisalbuminemia and subsequent diagnosis of diabetes
mellitus. Case 2 involves a 71-year-old patient presenting
with worsening lower back pain and bisalbuminemia,
ultimately leading to a diagnosis of diabetes mellitus.
Discussion highlights the significance of diabetes as
a potential contributing factor to acquired
bisalbuminemia, as suggested by previous case reports
and prospective studies. While further research with
larger cohorts is needed to confirm these findings, the
inclusion of diabetes biological workup in
bisalbuminemia cases may aid in early detection and
management.
In conclusion, this study underscores the potential
association between uncontrolled diabetes and acquired
bisalbuminemia, suggesting the importance of assessing
for diabetes in such cases to improve diagnostic
approaches for this rare condition.