Exploring the Anticancer Efficacy of Tinospora Cordifolia: Revolutionizing Cancer Care Through Herbal Science


Authors : Roshan Gupta; Chanda Sharma; Ravi Ram

Volume/Issue : Volume 10 - 2025, Issue 9 - September


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DOI : https://doi.org/10.38124/ijisrt/25sep1486

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Abstract : Cancer continues to be one of the most impactful causes of morbidity & motility changes at the global level and it marked by the uncontrolled cell division of anomalous cell, however common treatment, like chemotherapy and radiation therapy, have a played important role, they have an effect beside of unwanted side effect, which allows researching an alternative therapies, a famous and traditional medicinal herb in Ayurveda medicine, tinospora cordifoila, it has acquired importance in the field of cancer treatment as it include various bio-active molecule such as alkaloids, glycosides, and diterpenoid lactones. In this review, we summarize the regulatory or modulating roles of Tinospora cordifolia on major molecular pathways, including NF-κB, apoptosis, angiogenesis inhibition, and help immune response have anticancer potential. In vitro & some limited clinical studies show efficacy against Breast, cervical, and brain cancer with very list side effects. But more large-scale clinical studies are needed to confirm its safety and efficacy in the human population.

Keywords : Tinospora Cordifolia, Anticancer, Method of Preparation, Immune Modulation, Ayurvedic Medicine, Breast Cancer, Lung Cancer, Brain Cancer.

References :

  1. Sharma, A., Saggu, S. K., Mishra, R., & Kaur, G. (2019). Anti-brain cancer activity of chloroform and hexane extracts of Tinospora cordifolia Miers: an in vitro perspective. Annals of Neurosciences, 26(1), 10–20. https://doi.org/10.5214/ans.0972.7531.260104
  2. Bhatt, M. L. B., Ministry of Ayush, Government of India, Ministry of Ayush, GOI, India, DG (I/c), CCRAS, New Delhi, Director, Ramaiah Indic Specialty Ayurveda, Bengaluru, Head, Dept. of Neurology, K.G. Medical University, Lucknow, Senior Principal Scientist, CSIR-Institute of Genomics & Integrative Biology, New Delhi, & Associate Professor, All India Institute of Ayurveda, New Delhi. (2022). Guduchi (Tinospora cordifolia) Technical Dossier. https://www.researchgate.net/publication/366953016_Technical_Dossier_on_Guduchi_Tinospora_cordifolia
  3. Lin, Y., Bai, L., Chen, W., & Xu, S. (2009). The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opinion on Therapeutic Targets, 14(1), 45–55. https://doi.org/10.1517/14728220903431069
  4. Upadhyay, A., Kumar, K., Kumar, A., & Mishra, H. (2010). Tinospora cordifolia (Willd.) Hook. f. and Thoms. “(Guduchi) - Validation of the Ayurvedic pharmacology through experimental and clinical studies.” (“Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Guduchi ...”) International Journal of Ayurveda Research, 1(2), 112. https://doi.org/10.4103/0974-7788.64405
  5. Shah, M. S., 1, Shinde, A. R., 2, Jagtap, D. R., 3, Kamble, S. M., 4, Nagargoje, S., 5, Shewale, K. P., 6, & Oswal, R. J., 7. (2020). “TINOSPORA CORDIFOLIA: ONE OF THE AYURVEDIC PLANTS OF CORONIL FORMULATION FOR COVID-19.” (“Tinospora cordifolia (Willd.) Hook.f. & Thomson: A Review of its role ...”) In European Journal of Biomedical and Pharmaceutical Sciences (Vol. 7, Issue 8, pp. 257–267). http://www.ejbps.com
  6. “Polu, P. R., Nayanbhirama, U., Khan, S., & Maheswari, R. (2017).” (“Bio-efficacy and Radical scavenging activity of Terminalia paniculata”) “Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd).” (“Characterization of phytochemicals and validation of antioxidant and ...”) BMC Complementary and Alternative Medicine, 17(1). https://doi.org/10.1186/s12906-017-1953-3
  7. Ahmad, R., Srivastava, A. N., & Khan, M. A. (2015). Evaluation of in vitro anticancer activity of the stem of Tinospora cordifolia against human breast cancer and Vero cell lines. Journal of Medicinal Plants Studies, 3(4), 33–37.
  8. Role of the NFκB-signaling pathway in cancer. (2018). In OncoTargets and Therapy (Vol. 11, pp. 2063–2073). http://dx.doi.org/10.2147/OTT.S161109
  9. “Polu, P. R., Nayanbhirama, U., Khan, S., & Maheswari, R. (2017).” (“Bio-efficacy and Radical scavenging activity of Terminalia paniculata”) “Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd).” (“Characterization of phytochemicals and validation of antioxidant and ...”) BMC Complementary and Alternative Medicine, 17(1). https://doi.org/10.1186/s12906-017-1953-3
  10. Mittal, J., Pal, U., Sharma, L., Verma, A. K., Ghosh, M., & Sharma, M. M. (2020). (“Plant-mediated synthesis of silver nanoparticles: unlocking their ...”) Unveiling the cytotoxicity of photosynthesized silver nanoparticles using Tinospora cordifolia leaves against human lung adenocarcinoma A549 cell line. (“Teaching Faculties”) IET Nano biotechnology, 14(3), 230–238. https://doi.org/10.1049/iet-nbt.2019.0335
  11. Pawar, A. R., Chougule, A. T., Kamble, J. R., Salokhe, P., Chougule, N. B., & Ashokrao Mane Institute of Pharmacy. (2024). Tinospora cordifolia – as an anticancer agent: recent and advanced study. In INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES (Vol. 2, Issue 1, pp. 707–716) [Journal-article]. https://doi.org/10.5281/zenodo.10578070

Cancer continues to be one of the most impactful causes of morbidity & motility changes at the global level and it marked by the uncontrolled cell division of anomalous cell, however common treatment, like chemotherapy and radiation therapy, have a played important role, they have an effect beside of unwanted side effect, which allows researching an alternative therapies, a famous and traditional medicinal herb in Ayurveda medicine, tinospora cordifoila, it has acquired importance in the field of cancer treatment as it include various bio-active molecule such as alkaloids, glycosides, and diterpenoid lactones. In this review, we summarize the regulatory or modulating roles of Tinospora cordifolia on major molecular pathways, including NF-κB, apoptosis, angiogenesis inhibition, and help immune response have anticancer potential. In vitro & some limited clinical studies show efficacy against Breast, cervical, and brain cancer with very list side effects. But more large-scale clinical studies are needed to confirm its safety and efficacy in the human population.

Keywords : Tinospora Cordifolia, Anticancer, Method of Preparation, Immune Modulation, Ayurvedic Medicine, Breast Cancer, Lung Cancer, Brain Cancer.

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Paper Submission Last Date
31 - December - 2025

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