Authors :
Roshan Gupta; Chanda Sharma; Ravi Ram
Volume/Issue :
Volume 10 - 2025, Issue 9 - September
Google Scholar :
https://tinyurl.com/mv5h43e5
Scribd :
https://tinyurl.com/ca8xvwbk
DOI :
https://doi.org/10.38124/ijisrt/25sep1486
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Note : Google Scholar may take 30 to 40 days to display the article.
Abstract :
Cancer continues to be one of the most impactful causes of morbidity & motility changes at the global level and
it marked by the uncontrolled cell division of anomalous cell, however common treatment, like chemotherapy and radiation
therapy, have a played important role, they have an effect beside of unwanted side effect, which allows researching an
alternative therapies, a famous and traditional medicinal herb in Ayurveda medicine, tinospora cordifoila, it has acquired
importance in the field of cancer treatment as it include various bio-active molecule such as alkaloids, glycosides, and
diterpenoid lactones. In this review, we summarize the regulatory or modulating roles of Tinospora cordifolia on major
molecular pathways, including NF-κB, apoptosis, angiogenesis inhibition, and help immune response have anticancer
potential. In vitro & some limited clinical studies show efficacy against Breast, cervical, and brain cancer with very list side
effects. But more large-scale clinical studies are needed to confirm its safety and efficacy in the human population.
Keywords :
Tinospora Cordifolia, Anticancer, Method of Preparation, Immune Modulation, Ayurvedic Medicine, Breast Cancer, Lung Cancer, Brain Cancer.
References :
- Sharma, A., Saggu, S. K., Mishra, R., & Kaur, G. (2019). Anti-brain cancer activity of chloroform and hexane extracts of Tinospora cordifolia Miers: an in vitro perspective. Annals of Neurosciences, 26(1), 10–20. https://doi.org/10.5214/ans.0972.7531.260104
- Bhatt, M. L. B., Ministry of Ayush, Government of India, Ministry of Ayush, GOI, India, DG (I/c), CCRAS, New Delhi, Director, Ramaiah Indic Specialty Ayurveda, Bengaluru, Head, Dept. of Neurology, K.G. Medical University, Lucknow, Senior Principal Scientist, CSIR-Institute of Genomics & Integrative Biology, New Delhi, & Associate Professor, All India Institute of Ayurveda, New Delhi. (2022). Guduchi (Tinospora cordifolia) Technical Dossier. https://www.researchgate.net/publication/366953016_Technical_Dossier_on_Guduchi_Tinospora_cordifolia
- Lin, Y., Bai, L., Chen, W., & Xu, S. (2009). The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opinion on Therapeutic Targets, 14(1), 45–55. https://doi.org/10.1517/14728220903431069
- Upadhyay, A., Kumar, K., Kumar, A., & Mishra, H. (2010). Tinospora cordifolia (Willd.) Hook. f. and Thoms. “(Guduchi) - Validation of the Ayurvedic pharmacology through experimental and clinical studies.” (“Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Guduchi ...”) International Journal of Ayurveda Research, 1(2), 112. https://doi.org/10.4103/0974-7788.64405
- Shah, M. S., 1, Shinde, A. R., 2, Jagtap, D. R., 3, Kamble, S. M., 4, Nagargoje, S., 5, Shewale, K. P., 6, & Oswal, R. J., 7. (2020). “TINOSPORA CORDIFOLIA: ONE OF THE AYURVEDIC PLANTS OF CORONIL FORMULATION FOR COVID-19.” (“Tinospora cordifolia (Willd.) Hook.f. & Thomson: A Review of its role ...”) In European Journal of Biomedical and Pharmaceutical Sciences (Vol. 7, Issue 8, pp. 257–267). http://www.ejbps.com
- “Polu, P. R., Nayanbhirama, U., Khan, S., & Maheswari, R. (2017).” (“Bio-efficacy and Radical scavenging activity of Terminalia paniculata”) “Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd).” (“Characterization of phytochemicals and validation of antioxidant and ...”) BMC Complementary and Alternative Medicine, 17(1). https://doi.org/10.1186/s12906-017-1953-3
- Ahmad, R., Srivastava, A. N., & Khan, M. A. (2015). Evaluation of in vitro anticancer activity of the stem of Tinospora cordifolia against human breast cancer and Vero cell lines. Journal of Medicinal Plants Studies, 3(4), 33–37.
- Role of the NFκB-signaling pathway in cancer. (2018). In OncoTargets and Therapy (Vol. 11, pp. 2063–2073). http://dx.doi.org/10.2147/OTT.S161109
- “Polu, P. R., Nayanbhirama, U., Khan, S., & Maheswari, R. (2017).” (“Bio-efficacy and Radical scavenging activity of Terminalia paniculata”) “Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd).” (“Characterization of phytochemicals and validation of antioxidant and ...”) BMC Complementary and Alternative Medicine, 17(1). https://doi.org/10.1186/s12906-017-1953-3
- Mittal, J., Pal, U., Sharma, L., Verma, A. K., Ghosh, M., & Sharma, M. M. (2020). (“Plant-mediated synthesis of silver nanoparticles: unlocking their ...”) Unveiling the cytotoxicity of photosynthesized silver nanoparticles using Tinospora cordifolia leaves against human lung adenocarcinoma A549 cell line. (“Teaching Faculties”) IET Nano biotechnology, 14(3), 230–238. https://doi.org/10.1049/iet-nbt.2019.0335
- Pawar, A. R., Chougule, A. T., Kamble, J. R., Salokhe, P., Chougule, N. B., & Ashokrao Mane Institute of Pharmacy. (2024). Tinospora cordifolia – as an anticancer agent: recent and advanced study. In INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES (Vol. 2, Issue 1, pp. 707–716) [Journal-article]. https://doi.org/10.5281/zenodo.10578070
Cancer continues to be one of the most impactful causes of morbidity & motility changes at the global level and
it marked by the uncontrolled cell division of anomalous cell, however common treatment, like chemotherapy and radiation
therapy, have a played important role, they have an effect beside of unwanted side effect, which allows researching an
alternative therapies, a famous and traditional medicinal herb in Ayurveda medicine, tinospora cordifoila, it has acquired
importance in the field of cancer treatment as it include various bio-active molecule such as alkaloids, glycosides, and
diterpenoid lactones. In this review, we summarize the regulatory or modulating roles of Tinospora cordifolia on major
molecular pathways, including NF-κB, apoptosis, angiogenesis inhibition, and help immune response have anticancer
potential. In vitro & some limited clinical studies show efficacy against Breast, cervical, and brain cancer with very list side
effects. But more large-scale clinical studies are needed to confirm its safety and efficacy in the human population.
Keywords :
Tinospora Cordifolia, Anticancer, Method of Preparation, Immune Modulation, Ayurvedic Medicine, Breast Cancer, Lung Cancer, Brain Cancer.