Authors :
Sara Moghimi; B. P. Harini; Mohammadsina Zeidabadinejad
Volume/Issue :
Volume 7 - 2022, Issue 3 - March
Google Scholar :
http://bitly.ws/gu88
Scribd :
https://bit.ly/37CcFWt
DOI :
https://doi.org/10.5281/zenodo.6363703
Abstract :
Epileptic patients need to take medicine for
the rest of their lives. Teratogenic effect of antiepileptic
drugs must be extensively screened and investigated
utilizing animal model organisms. Drosophila is a great
model for efficiently screening prospective therapeutic
compounds and determining whether or not they are
teratogenic. Children exposed to antiepileptic drugs
(AEDs) during pregnancy had a greater percentage of
malformations than those who were not. Carbamazepine
(CBZ) is one of the most widely prescribed antiepileptic
drugs (AEDs). Congenital and developmental
malformations have been related to CBZ therapy during
pregnancy. Plant extracts are widely used in traditional
medicine to form the foundation of health care and to
cure various illnesses. Withania somnifera (W. somnifera)
is an anticonvulsant herbal medicine. The present study
is intended to evaluate the teratogenicity of W. somnifera
and CBZ in Drosophila paralytic mutant. As a wild-type
control, Drosophila Oregon-R strain were employed. The
results indicate that CBZ administration increases the
frequency of wing deformities in both Drosophila strains
in a dose-dependent manner. However, W. somnifera at
various concentrations is a safe therapeutic potent with
no teratogenicity while treating epilepsy in Drosophila
paralytic mutants.
Keywords :
Teratogenicity, Drosophila paralytic mutant, Withania somnifera, carbamazepine.
Epileptic patients need to take medicine for
the rest of their lives. Teratogenic effect of antiepileptic
drugs must be extensively screened and investigated
utilizing animal model organisms. Drosophila is a great
model for efficiently screening prospective therapeutic
compounds and determining whether or not they are
teratogenic. Children exposed to antiepileptic drugs
(AEDs) during pregnancy had a greater percentage of
malformations than those who were not. Carbamazepine
(CBZ) is one of the most widely prescribed antiepileptic
drugs (AEDs). Congenital and developmental
malformations have been related to CBZ therapy during
pregnancy. Plant extracts are widely used in traditional
medicine to form the foundation of health care and to
cure various illnesses. Withania somnifera (W. somnifera)
is an anticonvulsant herbal medicine. The present study
is intended to evaluate the teratogenicity of W. somnifera
and CBZ in Drosophila paralytic mutant. As a wild-type
control, Drosophila Oregon-R strain were employed. The
results indicate that CBZ administration increases the
frequency of wing deformities in both Drosophila strains
in a dose-dependent manner. However, W. somnifera at
various concentrations is a safe therapeutic potent with
no teratogenicity while treating epilepsy in Drosophila
paralytic mutants.
Keywords :
Teratogenicity, Drosophila paralytic mutant, Withania somnifera, carbamazepine.
