 Aim To evaluate the levels of serum albumin in healthy subjects, gingivitis and periodontitis patients and their correlation.  Materials and Methods  This study was conducted upon 60 subjects of both gender with age range of 25-50 years and the inclusion with exclusion criterias were considered.  Three groups were made with almost equal division of patients approximately 20 patients each in the group ; Clinically healthy subjects, gingivitis and periodontitis patients.  At baseline dental examinations were carried out with Bleeding on probing, Probing depth, Gingival index, Loss of clinical attachment were measured. By Albumin estimation kit – Bromocresol green method (BCG) the Serum albumin concentration was measured.  Results  The levels of mean serum albumin among healthy, gingivitis and periodontitis group was 4.03 ± 0.35, 4.09 ± 0.20, 3.72 ± 0.14 respectively. Three groups were compared for mean serum albumin levels using Kruskal Wallis test and results were found statistically significant (p<0.001).  The mean serum albumin levels in subjects among groups with Gingival index 0-1, 1.1-2 and 2.1-3 was 4.07±0.32, 4.04±0.29, 3.80±0.22 respectively. The difference of the mean serum albumin level among different gingival index score was found to be statistically significant (p<0.05).  The mean serum levels in subjects with loss of attachment less than 5 mm was 3.76 ± 0.12 and in subjects with attachment loss more than or equal to 5 mm was 3.68 ± 0.15. The comparison was done using Mann-Whitney U test and the differences in the mean serum albumin level was not significantly different( p>0.05) .  Conclusion Serum albumin concentration and the study groups had found an inverse association in this clinical trial. Also there was a finding that serum albumin level is reducing with an increase in gingival index and in loss of attachment.

Keywords : Gingivitis , Periodontitis, Serum Albumin.