Authors :
Yetunde O. Akinlaja; Damilare H. Adeyemi; Oluwatobi J. Oyedele; Rukayat A. Mustaph
Volume/Issue :
Volume 5 - 2020, Issue 12 - December
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/2X6Xzj2
Abstract :
Depressive disorders are extremely common
mental disorders with a life-time prevalence of about
16%. Estimations have shown that by the year 2020
depressive disorders would be the second most significant
contributor to the impairment of health globally. This
paper is aimed at evaluating the role of reserpine on male
reproductive hormones in rabbits. Ten sexually matured
rabbits were used for the study, animals were divided into
two groups (n=5). Group A (control) was given distilled
water, Group B was given reserpine. Blood was collected
for via cardiac puncture of the heart and various organs
like epididymis, corpus carvenosa and testes were
harvested for histological analysis. Data obtained were
analyzed using Student’s T-test and p<0.05 was
considered significant. The result obtained showed
significant reduction in serum testosterone level, while
serum LH and FSH level remained unchanged.
Epididymal weight result showed significant decrease
while testicular weight and corpus carvenosa remained
unchanged. The cytoarchitecture of testicular tissue
revealed severe damaged to the leydig cell, while that of
penile tissue showed loosened connective tissues in corpus
spongiosum. This study therefore confirms that reserpine
alters serum testosterone levels in male rabbits but the
mechanism still remains unclear.
Keywords :
Depression; Erectile Dysfunction; Testosterone; Luteinizing Hormone; Follicle Stimulating Hormone; Epididymis
Depressive disorders are extremely common
mental disorders with a life-time prevalence of about
16%. Estimations have shown that by the year 2020
depressive disorders would be the second most significant
contributor to the impairment of health globally. This
paper is aimed at evaluating the role of reserpine on male
reproductive hormones in rabbits. Ten sexually matured
rabbits were used for the study, animals were divided into
two groups (n=5). Group A (control) was given distilled
water, Group B was given reserpine. Blood was collected
for via cardiac puncture of the heart and various organs
like epididymis, corpus carvenosa and testes were
harvested for histological analysis. Data obtained were
analyzed using Student’s T-test and p<0.05 was
considered significant. The result obtained showed
significant reduction in serum testosterone level, while
serum LH and FSH level remained unchanged.
Epididymal weight result showed significant decrease
while testicular weight and corpus carvenosa remained
unchanged. The cytoarchitecture of testicular tissue
revealed severe damaged to the leydig cell, while that of
penile tissue showed loosened connective tissues in corpus
spongiosum. This study therefore confirms that reserpine
alters serum testosterone levels in male rabbits but the
mechanism still remains unclear.
Keywords :
Depression; Erectile Dysfunction; Testosterone; Luteinizing Hormone; Follicle Stimulating Hormone; Epididymis
