The study of psychotropic drugs prescription pattern gives an image of drug preference and rationality of medication use. Psychological health when neglected for too long becomes crucial to the overall well-being of individuals, societies and countries. Utilization of psychotropic medications, consequences on actual life efficiency in clinical practice need continuous study. Understanding how inseparable psychological and physical health really are, and how their influence on each other is intricate and profound. This study aims to analyze antipsychotic prescriptions and compare whether they confirm to the primary prescribing indicators by WHO.  Methodology: A Retrospective observational study was performed in the department of Psychiatry in Malla Reddy College of Pharmacy on 101 subjects, who were selected based on inclusion and exclusion criteria. Prescriptions along with participant demographics were documented on the data collection form, the medications were classified accordingly and was then analyzed using simple mean method and percentage method. Statistical clarification was done to decode the unbiased analysis and final conclusions were drawn.  Results: Out of 101 patients analyzed, 60% were males and 40% were females, 77% were below 50 years. According to the study findings the most commonly used psychotropic drugs were lorazepam (25%) and haloperidol (18.25%). 63.39 is the percentage of antipsychotropic drugs prescribed from Essential Drugs List (EDL). Oral route was the most frequently used route of administration (61%) compared to Intramuscular (23%) and Intravenous (16%). The prescription pattern analysis also reveals that polytherapy was most commonly seen (35%) when compared with monotherapy (1%).  Conclusion: In the present study, Traditional drugs (TCA’s, Atypical and typical antipsychotics) were prescribed more in comparison to Novel antidepressants (SSRIs and SNRIs). Medications were prescribed rationally and judiciously. Though the prescribed percentage of drugs from EDL (Essential Drug List) was high, drug accuracy with the disorder was low, which has to be improved. Percentage of generic drug prescribing is low, where the challenges on frequent use of brand names to be address.

Keywords : Depression, Antipsychotics, Antidepressants, Post Traumatic Stress Disorder (PTSD), Psychotherapy, Substance Abuse/Dependence, Bipolar Disorder and Anxiety.