A rapid, accurate and precise HPTLC method has been developed for the estimation of Piracetam in bulk and Pharmaceutical formulation. In this method standard and sample solutions of Piracetam were applied on pre-coated 6 x 10 silica gel 60F254 TLC plate, and developed using chloroform: methanol:glacial acetic acid: triethyl amine (16:4:0.2:0.2) as mobile phase. A Camag HPTLC system comprising of Camag Linomat -5-applicator, Camag twin trough chamber, Camag TLC-3 scanner was used for the analysis. The drugs on the plate were scanned at 254 nm. The dynamic linearity range was 2µl, 4µl, 6µl, 8µl & 10µl for Piracetam. The method was validated for precision, accuracy and recovery and the results were satisfactory.Precision (%RSD-0.31), Accuracy (%RSD-0.59) values are under the limit. According to ICH guidelines the values of accuracy and precision should be in the limit less than 2.

Keywords : Estimation, HPTLC, Piracetam