Authors :
Suparna Maji; Soumyadipta Das
Volume/Issue :
Volume 6 - 2021, Issue 7 - July
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/3y6Hk6B
Abstract :
Epstein Barr Virus (EBV), belonging to the
family of herpes virus, widely responsible for initiating a
long-lasting infection that infects more than 90% of the
adult human population world-wide. Apart from being a
chronic B-Lymphocyte infecting virus with common
symptoms associated with fever, sore throat,
lymphadenopathy etc., the viral proteins have been
reported to be linked to different types of human
carcinomas & lymphomas in the long run. The approach
of this review is mostly to bring forward the insights of
some of the potent carcinomas that are directly related to
the pathogenesis of this virus, elucidating the viral
proteins -: EBNA-1, EBNA-2, EBNA-LP, EBNA-3A, 3B,
3C, LMP-1, their direct association with human p53, p63,
p73 & their isoforms in regulating the tumour inducing
pathways, along with this some of the recent therapeutic
approaches in preventing the EBV linked carcinogenesis
has also been incorporated in this review.
Keywords :
Epstein Barr Virus (EBV), p53, p63, p73, EBNA, LMP, Lymphoma, Malignancy, CRISPR, CAR-T Cell
Epstein Barr Virus (EBV), belonging to the
family of herpes virus, widely responsible for initiating a
long-lasting infection that infects more than 90% of the
adult human population world-wide. Apart from being a
chronic B-Lymphocyte infecting virus with common
symptoms associated with fever, sore throat,
lymphadenopathy etc., the viral proteins have been
reported to be linked to different types of human
carcinomas & lymphomas in the long run. The approach
of this review is mostly to bring forward the insights of
some of the potent carcinomas that are directly related to
the pathogenesis of this virus, elucidating the viral
proteins -: EBNA-1, EBNA-2, EBNA-LP, EBNA-3A, 3B,
3C, LMP-1, their direct association with human p53, p63,
p73 & their isoforms in regulating the tumour inducing
pathways, along with this some of the recent therapeutic
approaches in preventing the EBV linked carcinogenesis
has also been incorporated in this review.
Keywords :
Epstein Barr Virus (EBV), p53, p63, p73, EBNA, LMP, Lymphoma, Malignancy, CRISPR, CAR-T Cell
