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Enhancing Non-Invasive Diabetes Diagnosis: A Comparative Analysis of Deep Learning Models using SAM-Supported U-Net for Tongue Segmentation


Authors : Hasan Erdinç Koçer; Mohammed Qaimaz Ali

Volume/Issue : Volume 11 - 2026, Issue 5 - May


Google Scholar : https://tinyurl.com/y5syn9uf

Scribd : https://tinyurl.com/2zbfatxh

DOI : https://doi.org/10.38124/ijisrt/26May820

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Diabetes is a major public health concern necessitating early diagnosis to prevent severe long-term systemic complications. This study presents a comprehensive comparative analysis of classical machine learning and deep learning approaches for non-invasive diabetes detection using tongue images. The experimental framework evaluates both segmented and non-segmented data to isolate the impact of region-of-interest extraction. For precise localization, a novel preprocessing pipeline is proposed: the tongue region is automatically detected using a Segment Anything Model (SAM)-based bounding box approach, followed by pixel-level segmentation via a U-Net architecture. To improve model robustness, deterministic data augmentation techniques are applied. In the classical machine learning phase, handcrafted features—including GLCM, LBP, HOG, and SIFT—are extracted and classified using Support Vector Machine (SVM) and Random Forest (RF). Conversely, the deep learning phase utilizes transfer learning with ResNet50, VGG16, EfficientNet-B4, and DenseNet169 architectures. Experimental results demonstrate that the SAM-supported segmentation significantly boosts classification performance by eliminating background noise. Specifically, the ResNet50 model achieved the highest performance with 97.92% accuracy, precision, and recall on the segmented dataset. These findings validate that AI-driven tongue image analysis, particularly when enhanced by robust segmentation, offers a highly accurate, rapid, and non-invasive alternative for clinical diabetes screening. Overall, deep learning approaches proved superior to classical methods in modeling the complex texture and color variations of the tongue. These findings confirm the clinical potential of the proposed system as an effective screening tool. Future work will focus on dataset expansion and mobile platform integration to facilitate realtime diagnosis.

Keywords : Diabetes Diagnosis, Tongue Image Analysis, Deep Learning, Segment Anything Model (SAM), Medical Image Segmentation, Non-Invasive Screening.

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Diabetes is a major public health concern necessitating early diagnosis to prevent severe long-term systemic complications. This study presents a comprehensive comparative analysis of classical machine learning and deep learning approaches for non-invasive diabetes detection using tongue images. The experimental framework evaluates both segmented and non-segmented data to isolate the impact of region-of-interest extraction. For precise localization, a novel preprocessing pipeline is proposed: the tongue region is automatically detected using a Segment Anything Model (SAM)-based bounding box approach, followed by pixel-level segmentation via a U-Net architecture. To improve model robustness, deterministic data augmentation techniques are applied. In the classical machine learning phase, handcrafted features—including GLCM, LBP, HOG, and SIFT—are extracted and classified using Support Vector Machine (SVM) and Random Forest (RF). Conversely, the deep learning phase utilizes transfer learning with ResNet50, VGG16, EfficientNet-B4, and DenseNet169 architectures. Experimental results demonstrate that the SAM-supported segmentation significantly boosts classification performance by eliminating background noise. Specifically, the ResNet50 model achieved the highest performance with 97.92% accuracy, precision, and recall on the segmented dataset. These findings validate that AI-driven tongue image analysis, particularly when enhanced by robust segmentation, offers a highly accurate, rapid, and non-invasive alternative for clinical diabetes screening. Overall, deep learning approaches proved superior to classical methods in modeling the complex texture and color variations of the tongue. These findings confirm the clinical potential of the proposed system as an effective screening tool. Future work will focus on dataset expansion and mobile platform integration to facilitate realtime diagnosis.

Keywords : Diabetes Diagnosis, Tongue Image Analysis, Deep Learning, Segment Anything Model (SAM), Medical Image Segmentation, Non-Invasive Screening.

Paper Submission Last Date
30 - June - 2026

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