Mandibular premolars are usually thought to be easy to treat endodontically but variations in their anatomic configuration make them a difficult task to accomplish. The possibility of additional root canals should always be kept in mind when performing endodontic treatment with such cases. Adequate knowledge of pulp canal anatomy, proper radiographic interpretation, incorporation of CBCT, and dental operating microscope are prerequisites for the best possible outcome in complex root canal treatment. This case series presents a relatively uncommon clinical case of mandibular premolars with two and three canal configurations managed with the help of DOM.

Keywords : Complex Anatomy, Endodontic Enigma, Mandibular Premolar.