Authors :
Pradeepa Subramanian; Chithra Shanmugasundaram; Jesteena Johney; Ragunathan R; Sam Ebenezer Rajadas
Volume/Issue :
Volume 8 - 2023, Issue 5 - May
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/2nrrj2fc
DOI :
https://doi.org/10.5281/zenodo.8042674
Abstract :
One of the main cancers that kill women
globally is cervical cancer, which has limited
infectiousness and behaves epidemiologically like a
vaginal illness. In a concept of multifactorial, stepwise
carcinogenesis at the cervix uteri, smoking, and human
papillomavirus (HPV) 16/18 are currently significant
problems. Hence there is a need for therapeutics with
lesser or no side effects. Grapes (Vitis vinifera) have
recently gained scientific attention. Its rich high
polyphenol content has been shown to improve human
health, particularly in the prevention of cancer and
cardiovascular disease. Resveratrol, quercetin,
catechin/epicatechin, and other polyphenol bioactive
compounds are present in significant amounts in grapes.
Preservation of these contents is challenging to achieve
significant shelf-life. In this study, we employed
microencapsulation techniques to design a carrier
medium that could preserve the Using the agar diffusion
method, the encapsulated aqueous grape seed extract’s
antibacterial activity was assessed against Gram-
negative bacteria, and anticancer activity was analyzed
using Hela-cell lines.The outcome of the study, clearly
indicates that the encapsulation does not alter the
activity of the lead molecules present in the grape seed
extract.
Keywords :
Vitis Vinifera, Cervical cancer, Antioxidants, Polyphenol, Antibacterial and anti-cancer activity.
One of the main cancers that kill women
globally is cervical cancer, which has limited
infectiousness and behaves epidemiologically like a
vaginal illness. In a concept of multifactorial, stepwise
carcinogenesis at the cervix uteri, smoking, and human
papillomavirus (HPV) 16/18 are currently significant
problems. Hence there is a need for therapeutics with
lesser or no side effects. Grapes (Vitis vinifera) have
recently gained scientific attention. Its rich high
polyphenol content has been shown to improve human
health, particularly in the prevention of cancer and
cardiovascular disease. Resveratrol, quercetin,
catechin/epicatechin, and other polyphenol bioactive
compounds are present in significant amounts in grapes.
Preservation of these contents is challenging to achieve
significant shelf-life. In this study, we employed
microencapsulation techniques to design a carrier
medium that could preserve the Using the agar diffusion
method, the encapsulated aqueous grape seed extract’s
antibacterial activity was assessed against Gram-
negative bacteria, and anticancer activity was analyzed
using Hela-cell lines.The outcome of the study, clearly
indicates that the encapsulation does not alter the
activity of the lead molecules present in the grape seed
extract.
Keywords :
Vitis Vinifera, Cervical cancer, Antioxidants, Polyphenol, Antibacterial and anti-cancer activity.