Authors : Dr. Dishantkumar Sonpal; Dr. Khalid Mohammed Agwani; Dr. Sushmit Rajput; Dr. Saloni Chordia; Dr. Shubham Pachwaria; Dr. Malaika Dedhia

Volume/Issue : Volume 10 - 2025, Issue 12 - December

Google Scholar : https://tinyurl.com/bpajbr7p

Scribd : https://tinyurl.com/db2w6dpe

DOI : https://doi.org/10.38124/ijisrt/25dec220

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Abstract : Background: Simvastatin, a commonly prescribed HMG-CoA reductase inhibitor, has gained considerable attention in oral and maxillofacial practice due to its wide range of biological actions that extend far beyond lipid control. Experimental and clinical research has shown that simvastatin can promote bone formation, support odontoblastic activity, reduce inflammatory responses, and interfere with the virulence of oral biofilms. These properties make it a compelling candidate for enhancing soft- and hard-tissue healing in procedures where predictable regeneration is essential.  Aim: This review aims to critically examine the emerging regenerative applications of simvastatin in oral and maxillofacial surgery. It synthesizes current evidence from original studies to evaluate its influence on bone repair, pulpal regeneration, periodontal healing, microbial modulation, and inflammatory control, while highlighting its potential role in improving clinical outcomes.  Conclusion: The available evidence indicates that simvastatin meaningfully contributes to craniofacial tissue regeneration through its osteogenic, odontogenic, anti-inflammatory, and antimicrobial effects. It has demonstrated the ability to enhance extraction socket healing, improve bone density, and support dentin–pulp repair. Its capacity to modulate the inflammatory environment and reduce microbial burden further strengthens its usefulness in postoperative and infection-prone conditions. Given its affordability, accessibility, and compatibility with various local delivery systems, simvastatin represents a promising adjunct in regenerative oral and maxillofacial therapies. Future research should focus on optimizing dosage, refining delivery vehicles, and establishing standardized clinical protocols to broaden its clinical application.

Keywords : Simvastatin; Bone Regeneration; Wound Healing; Alveolar Bone Loss; Oral Surgical Procedures.

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