Authors : Farinde Rukayat Adesewa; Komolafe Omobola Aderibigbe

Volume/Issue : Volume 9 - 2024, Issue 5 - May

Google Scholar : https://tinyurl.com/mf5cs4d2

Scribd : https://tinyurl.com/4a845zc7

DOI : https://doi.org/10.38124/ijisrt/IJISRT24MAY1281

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Abstract : Background: Alcohol consumption is associated with several cardiovascular diseases such as heart failure, left ventricular hypertrophy, as well as with other disorders. This study was designed to determine the cardioprotective effect of celery (Apium graveolens) extract in attenuating perturbations arising from alcohol ingestion on left ventricular injury in adult Wistar rats.  Methods: Thirty male Wistar rats weighing 120g -160g were used for this study. The rats were divided into six (6) groups A, B, C, D, E &F five (5) rats each. The rats in group (A) served as control and received standard pellet, while groups B, C, D, E and F were administered orally with 8ml/kg b. w of ethanol and 100mg/kg, 150mg/kg, 200mg/kg of methanol extract of Apium graveolens (MEAG) were given to group C, D and E and 25mg of propranolol was given to group F orally. Group A and B were administered with 2ml/kg b. w distilled water.  Results: The relative heart weight, level of serum cardiac troponin I and left ventricular wall thickness of the ethanol-induced rats were significantly increase (F = 7.64; p = 0.002), (F = 22.66; p = 0.001) and (F = 85.29; p < 0.001) when compared with the control and across all experimental groups in this study. Group treated with MEAG also showed regular striations.Conclusion: This study indicates that MEAG has cardioprotective effects on these perturbations.

Keywords : Methanol; Apium Graveolens; Heart; Ethanol; Left Ventricle; Celery; Wistar Rats.

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