This study has been carried out to assess” the effect of teaching and learning resources on students’ academic performance with case of selected schools in Burera district in Rwanda 2019-2022. To achieve the objectives of the study, source of data was both primary and secondary data, questionnaire and observation were the techniques to be employed to obtain the primary data and second data. The researchers have been used purposive sampling in conformity to the realization of the objectives of the study. The suggested respondents were teachers, school administrators and students both in GS GITARE II and GS KAYENZI. Therefore, the sample size for students were 92 from both GS KAYENZI and GS GITARE II while sample size from teachers and school administrators were 29 with total of 121 respondents. For collecting data researcher organized well-structured questionnaires. Data has been edited and sorted for the next stage. The data have been presented in statistical tables, with frequencies and percentage for classification of responses by statistical package of social science (SPSS) for easier analysis interpretation. Researcher has used SPSS to analysis and interpretation. Research has used SPSS to analyze or examine the relationship between the variables under study. The results found out the in the table 11 indicated that 99.9% of the variation in the dependent variables (students’ academic performance) can be explained by physical resources means that there is positive significance effect on students’ academic performance. The table 14 indicated that 99.3 % of the variation in dependent variables (students’ academic working performance) can be explained by human resources means that there is positive significance effect on students’ academic performance. The table 17 indicated that 99.4% variable in dependent variable (students’ academic performance. The table 17:) indicated that 99.4% variable dependent variable (students’ academic performance) can be explained by financial resources students’ academic performance. Promoted the objectives of this research because the researcher come up with the conclusion that there is significance relationship between teaching and learning resources on students’ performance.