Authors :
Dele-Olawumi Bukola; Olanrewaju, O.I; Ayodeji, P.A; Adedayo, E.O
Volume/Issue :
Volume 5 - 2020, Issue 6 - June
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/3imuqd9
DOI :
10.38124/IJISRT20JUN630
Abstract :
Anaemia is a global public health problem, it is the
most common disorder of the blood, affecting about a
quarter of the people globally.
The effect of Sorghum bicolor, Carica papaya and
Hibiscus sabdariffa leaves extracts on weight,
Neutrophil and Lymphocyte Constituents of
Cyclophosphamide-induced Anaemia in adult male
albino rats was investigated.
Aqueous extracts of Five hundred grams (500g) of
each of the pulverized leaves was obtained in each case.
Forty non-drug treatment (40) adult male albino rats
were randomly allotted to eight (8) groups of five rats
each on the basis of body weight and their differences in
weights did not exceed 5g. Anaemia was induced in the
rats using Cyclophosphamide. Blood samples were
collected from the rats for biochemical analysis.
Hematological indices were determined using standard
procedure. One-way analysis of variance (ANOVA) and
Duncan Studentised New Multiple Range Test were
used to separate and compare means. The differences in
means were considered significant at 5% probability.
The group treated with 400mg/kgbw Sorghum
bicolor showed highest decrease (28.23%) in
neutrophils. Similarly, the group treated with
400mg/kgbw Sorghum bicolor had the highest increase
in lymphocytes (105.41%) compared to others.
Sorghum bicolor was significantly (P<0.05) higher in of
zinc, magnesium, manganese and phosphorus while
Hibiscus sabdariffa has the highest content of iron
This study demonstrated that Sorghum bicolor,
Carica papaya and Hibiscus sabdariffa leaf extracts
would be beneficial in boosting blood volume and
presents alternative to low cost management of
nutritional Anaemia.
Keywords :
Plant Leaves, Neutrophil, Lymphocyte, Anaemia, Albino Rats, Cyclophosphamide.
Anaemia is a global public health problem, it is the
most common disorder of the blood, affecting about a
quarter of the people globally.
The effect of Sorghum bicolor, Carica papaya and
Hibiscus sabdariffa leaves extracts on weight,
Neutrophil and Lymphocyte Constituents of
Cyclophosphamide-induced Anaemia in adult male
albino rats was investigated.
Aqueous extracts of Five hundred grams (500g) of
each of the pulverized leaves was obtained in each case.
Forty non-drug treatment (40) adult male albino rats
were randomly allotted to eight (8) groups of five rats
each on the basis of body weight and their differences in
weights did not exceed 5g. Anaemia was induced in the
rats using Cyclophosphamide. Blood samples were
collected from the rats for biochemical analysis.
Hematological indices were determined using standard
procedure. One-way analysis of variance (ANOVA) and
Duncan Studentised New Multiple Range Test were
used to separate and compare means. The differences in
means were considered significant at 5% probability.
The group treated with 400mg/kgbw Sorghum
bicolor showed highest decrease (28.23%) in
neutrophils. Similarly, the group treated with
400mg/kgbw Sorghum bicolor had the highest increase
in lymphocytes (105.41%) compared to others.
Sorghum bicolor was significantly (P<0.05) higher in of
zinc, magnesium, manganese and phosphorus while
Hibiscus sabdariffa has the highest content of iron
This study demonstrated that Sorghum bicolor,
Carica papaya and Hibiscus sabdariffa leaf extracts
would be beneficial in boosting blood volume and
presents alternative to low cost management of
nutritional Anaemia.
Keywords :
Plant Leaves, Neutrophil, Lymphocyte, Anaemia, Albino Rats, Cyclophosphamide.
