Authors :
TAIWO, A.A; Osifeso, O.O; Adepoju, M.A; Adeosun, Q,B
Volume/Issue :
Volume 9 - 2024, Issue 2 - February
Google Scholar :
http://tinyurl.com/mw4d5tz6
Scribd :
http://tinyurl.com/2s3w9zsc
DOI :
https://doi.org/10.5281/zenodo.10720365
Abstract :
Activated charcoal is a form of carbon
processed to have small and low-volume pores that
increases the surface area available for adsorption or
chemical reactions. The adsorbent nature of the activated
carbon can draw toxins from the body. It is cheap,
available, affordable, and accessible. In Nigeria, where
snake bites are rampant and the cost of chelation therapy
is high, it becomes imperative to explore readily available
and natural antidotes in the management of snake
poisoning. The present study investigates the effect of
prepared activated charcoal on sperm and hematological
parameters of wistar rats induced with snake venom. The
studied rats were grouped into four, four rats per group
based on the treatment: group I: Control, Group II;
Activated charcoal only, group III: activated charcoal and
venom and Group group IV: venom only. Semen samples
were thereafter collected from the cauda epididymis and
blood was collected through ocular puncture. Sperm
analysis and haematological parameters were determined
using standard procedures. The sperm cell count, motility,
live/dead and volume of cells were used to study the effect
of activated charcoal on testicle of Wistar rats induced
with snake venom. The result of sperm analysis showed
sperm motility for group I (75±2.40), group II (40±0.40),
group III (50±0.51), group IV (57.50±0.75); Live/dead
ratio: group I (96.5±0.76), group II (60±0.52), group III
(84.50± 2.19), group IV (93.25±2.24); sperm volume group
I (5.18±0.01), group II (5.18±0.01), group III (5.18±0.01),
group IV (5.18±0.01); while for the sperm count group I
(140±0.54), group II (77.25±1.89), group III (75.5±1.91),
group IV (79±1.99). The result of haematological
parameters indicated packed cell volume for group I
(47.00±1.92) group II (40.67±0.52), group III (44.00±1.93),
group IV (41.33±1.03) and the rest followed the same
trends. The result showed that activated charcoal has
beneficial haematological and reproductive effects in
Wistar rats. The sperm count was observed to have
increased significantly (p>0.05) which is an indication that
activated charcoal reduced spermatoxicity.
Keywords :
Activated Charcoal, Wistar Rats, Snake Venom, Spermatozoa, Haematological parameters.
Activated charcoal is a form of carbon
processed to have small and low-volume pores that
increases the surface area available for adsorption or
chemical reactions. The adsorbent nature of the activated
carbon can draw toxins from the body. It is cheap,
available, affordable, and accessible. In Nigeria, where
snake bites are rampant and the cost of chelation therapy
is high, it becomes imperative to explore readily available
and natural antidotes in the management of snake
poisoning. The present study investigates the effect of
prepared activated charcoal on sperm and hematological
parameters of wistar rats induced with snake venom. The
studied rats were grouped into four, four rats per group
based on the treatment: group I: Control, Group II;
Activated charcoal only, group III: activated charcoal and
venom and Group group IV: venom only. Semen samples
were thereafter collected from the cauda epididymis and
blood was collected through ocular puncture. Sperm
analysis and haematological parameters were determined
using standard procedures. The sperm cell count, motility,
live/dead and volume of cells were used to study the effect
of activated charcoal on testicle of Wistar rats induced
with snake venom. The result of sperm analysis showed
sperm motility for group I (75±2.40), group II (40±0.40),
group III (50±0.51), group IV (57.50±0.75); Live/dead
ratio: group I (96.5±0.76), group II (60±0.52), group III
(84.50± 2.19), group IV (93.25±2.24); sperm volume group
I (5.18±0.01), group II (5.18±0.01), group III (5.18±0.01),
group IV (5.18±0.01); while for the sperm count group I
(140±0.54), group II (77.25±1.89), group III (75.5±1.91),
group IV (79±1.99). The result of haematological
parameters indicated packed cell volume for group I
(47.00±1.92) group II (40.67±0.52), group III (44.00±1.93),
group IV (41.33±1.03) and the rest followed the same
trends. The result showed that activated charcoal has
beneficial haematological and reproductive effects in
Wistar rats. The sperm count was observed to have
increased significantly (p>0.05) which is an indication that
activated charcoal reduced spermatoxicity.
Keywords :
Activated Charcoal, Wistar Rats, Snake Venom, Spermatozoa, Haematological parameters.
