Authors : Azizah; Dodi Mariadi; Muhammad Fatikha Rizka; William Arthur Leo; Hanna’ Nadiyah; Eko Yulianto; Eva Sasmita; Renni Yuniati; Muhammad Nur

Volume/Issue : Volume 11 - 2026, Issue 5 - May

Google Scholar : https://tinyurl.com/4vf995eh

Scribd : https://tinyurl.com/mrrkc6nn

DOI : https://doi.org/10.38124/ijisrt/26May745

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Abstract : Ozonated Virgin Coconut Oil (OVCO) has emerged as a promising alternative therapy due to its stable bioactive compounds, such as ozonides and peroxides. However, the lack of standardized production parameters remains a major obstacle to its clinical application. This study aimed to obtain medical-grade ozone as a standard dose for OVCO production by mapping the quantitative relationship between ozone generator parameters, using the highest ozone capacity as a dosage reference, and by validating its antifungal efficacy in vivo. Ozone was generated using a Double Dielectric Barrier Discharge (DDBD) reactor in the form of a dual-cylinder made of borosilicate glass with a thickness of 0.2 cm, equipped with aluminum mesh electrodes measuring 6.2 cm in length, 2 cm in inner diameter, and 4.2 cm in outer diameter. Oxygen gas (O₂) was used as the feed gas with variations in applied voltage (2.7, 2.9, and 3.1 kV) and oxygen flow rates (0.4, 0.6, and 0.8 L/min). The results indicated that increasing the applied voltage significantly enhanced ozone production, with the highest capacity achieved at 3.1 kV and an oxygen flow rate of 0.6 L/min, yielding an ozone capacity of 0.408 g/min for dissolution into Virgin Coconut Oil (VCO). This maximum capacity was associated with an increase in the peroxide value (PV) and was used as the basis for OVCO dosage mapping. This standardization ensures consistent quality and effectiveness of OVCO as an antifungal therapy.

Keywords : Ozonated Virgin Coconut Oil (OVCO), Double Dielectric Barrier Discharge (DDBD), Ozone Capacity, Dosage Mapping.

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