Development of Nano-Niosomal Formulation of Alkaloids from Tylophora Indica for Improving Bioavailabilitythrough Oral Delivery


Authors : SANTHASEELAN. C; GOKULRAJ.B; ARJUN K

Volume/Issue : Volume 7 - 2022, Issue 5 - May

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3N3c2UT

DOI : https://doi.org/10.5281/zenodo.6663125

Phytochemicals, the natural biochemical substances produced by plants possess a range of medicinal values. These phytochemicals get into our system through food and bring different physiological benefits. However, many of these phytochemicals lack essential physicochemical properties that can provide them effective drug-likeness properties. Tylophora indica alkaloids are known for their therapeutic values especially in the cancer treatment domain. However, the physiochemical properties of these molecules limit their bioavailability greatly. This current research aimed at improving the bioavailability of Tylophora indicaalkaloids through the nanovector system, niosomes. Tylophora indica alkaloids were extracted, purified, screened and quantified. Niosomal constructs of the alkaloids were made, characterized through scanning electron microscope and ex- vivo studies were carried out using goat intestine. Results shows that niosomal formulation can increase bioavailability of Tylophora indica alkaloidstwo folds compared to the native alkaloid extract.

CALL FOR PAPERS


Paper Submission Last Date
29 - February - 2024

Paper Review Notification
In 1-2 Days

Paper Publishing
In 2-3 Days

Video Explanation for Published paper

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe