Development Formulation of Aloe Vera and Citrus Limon (L) Burm Extracts (ALOEMON) towards “Minimum Inhibitory Concentration” and “Minimum Kill Concentration” of Streptococcus SP


Authors : Nia Afdilla; Diyah Fatmasari; Masrifan Djamil

Volume/Issue : Volume 6 - 2021, Issue 8 - August

Scribd : https://bit.ly/3mZd1fy

Aloe Veraand Citrus Lemonare herbal plants that have various properties as antibacterial and antimicrobial. The combination of Aloe Veraand Citrus Lemonextracts is formulated in the form of a solution named ALOEMON that can be used as a natural disinfectant. Previous research has shown it can inhibit the growth of gram-negative and gram-positive bacteria. Streptococcus sp is one of the most common bacteria found after tooth extraction. The purpose of the study was to determine the effectiveness of ALOEMON as natural disinfectants by testing the Minimum Inhibitory Concentration (KHM) and the Minimum Killing Concentration (KBM) test, as well as to formulate and determine the physical stability. Using Quasy Experiment pretest-posttest with control group design. Sampling was done by identifying tooth extraction tools exposed to Streptococcus sp media Nutrient Agar (NA). Bacterial testing using spectrophotometry is a fast way to count the number of bacteria in a solution using the liquid dilution method. Subjects were divided into 2 groups, namely the intervention and control groups. This research uses a pharmaceutical chemistry laboratory and a microbiology laboratory. Statistical test using paired sample test, One way ANOVA. Results: effectiveness of inhibition (p=0.001), the effectiveness of the killing power of 75% concentration (p=0.002), the effectiveness of the killing power of the concentration of 50% (p=0.007). Conclusion: The formulation ALOEMON extracts has potential against KHM and KBM of bacteria.

Keywords : Aloe Veraand citrus Lemon, Minimum Inhibitory Concentration, Minimum Kill Concentration

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