Authors :
MUJAHID KHAN; AMIT SAHU; KAVITA R LOKSH
Volume/Issue :
Volume 8 - 2023, Issue 6 - June
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/4yzt3vsh
DOI :
https://doi.org/10.5281/zenodo.8103952
Abstract :
Rheumatoid arthritis (RA) is a chronic
autoimmune disease that affects the joints, leading to
progressive symmetric inflammation, cartilage destruction,
bone erosion, and disability. While the initial impact may
be limited to a few joints, later stages of the disease
commonly involve multiple joints and exhibit
extraarticular symptoms. The prevalence of RA varies
between 0.4% and 1.3% depending on factors such as
gender (with women being affected more frequently than
men), age (with the highest frequency of new RA diagnoses
occurring in the sixth decade of life), and the characteristics
of the patient population studied (RA frequency increasing
from south to north and being higher in urban compared to
rural areas). Quercetin, an important bioflavonoid found
in over twenty plant materials, is renowned for its various
beneficial effects, including anti-inflammatory,
antihypertensive, vasodilator, antiobesity,
antihypercholesterolemic, and antiatherosclerotic
activities. Free radicals play a significant role in the
development of diseases such as hypertension, vascular
disorders, and metabolic syndrome. However, the
effectiveness of quercetin as a drug is limited by its poor
permeation through the skin and its low deposition. To
address these challenges, the solubility of quercetin can be
improved by incorporating ethanol. Nanoliposomes serve
as excellent carriers for drugs due to their high solubility,
improved stability, and enhanced cellular uptake. It is
important to note that caution should be exercised when
topically applying high concentrations of ethanol to avoid
the risk of local irritation. Therefore, the development of an
appropriate carrier, such as nanoliposomes, for efficient
topical application of quercetin is necessary for the
treatment of rheumatoid arthritis.
Keywords :
Tablet, Immediate release layer, Sustained release layer, Pre-formulation characteristics, UV absorbance.
Rheumatoid arthritis (RA) is a chronic
autoimmune disease that affects the joints, leading to
progressive symmetric inflammation, cartilage destruction,
bone erosion, and disability. While the initial impact may
be limited to a few joints, later stages of the disease
commonly involve multiple joints and exhibit
extraarticular symptoms. The prevalence of RA varies
between 0.4% and 1.3% depending on factors such as
gender (with women being affected more frequently than
men), age (with the highest frequency of new RA diagnoses
occurring in the sixth decade of life), and the characteristics
of the patient population studied (RA frequency increasing
from south to north and being higher in urban compared to
rural areas). Quercetin, an important bioflavonoid found
in over twenty plant materials, is renowned for its various
beneficial effects, including anti-inflammatory,
antihypertensive, vasodilator, antiobesity,
antihypercholesterolemic, and antiatherosclerotic
activities. Free radicals play a significant role in the
development of diseases such as hypertension, vascular
disorders, and metabolic syndrome. However, the
effectiveness of quercetin as a drug is limited by its poor
permeation through the skin and its low deposition. To
address these challenges, the solubility of quercetin can be
improved by incorporating ethanol. Nanoliposomes serve
as excellent carriers for drugs due to their high solubility,
improved stability, and enhanced cellular uptake. It is
important to note that caution should be exercised when
topically applying high concentrations of ethanol to avoid
the risk of local irritation. Therefore, the development of an
appropriate carrier, such as nanoliposomes, for efficient
topical application of quercetin is necessary for the
treatment of rheumatoid arthritis.
Keywords :
Tablet, Immediate release layer, Sustained release layer, Pre-formulation characteristics, UV absorbance.
