Authors :
Dr. Sreevidya Puvvala; Dr. M. Sri Rekha; Y. Nagasurekha; Sk. Rizwana; Sk. Imran; M. Venkatesh Naik
Volume/Issue :
Volume 11 - 2026, Issue 6 - June
Google Scholar :
https://tinyurl.com/juh2huc9
Scribd :
https://tinyurl.com/bdfauwpx
DOI :
https://doi.org/10.38124/ijisrt/26jun2069
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Cheilitis is an inflammatory disorder of the lips characterized by dryness, fissuring, erythema, scaling, and
susceptibility to microbial infections. Conventional lip care products primarily provide cosmetic benefits and frequently
contain synthetic pigments that may induce allergic reactions and irritation. The present study aimed to develop and
comparatively evaluate natural pigment-enriched polyherbal therapeutic lipsticks intended for supportive management of
cheilitis. Three formulations were prepared using natural pigments obtained from dragon fruit peel, beetroot, and rose
petals along with neem oil, betel leaf extract, henna leaf extract, coconut oil, soy wax, vitamin E, and rose oil. Lipsticks
were prepared by the fusion molding method and evaluated for organoleptic characteristics, melting point, breaking
strength, spreadability, pH, homogeneity, skin irritation, stability, antioxidant activity, and antimicrobial activity. The
formulations exhibited satisfactory physicochemical properties and acceptable stability. Beetroot-based formulation
demonstrated the highest antioxidant activity (84.7 ± 1.5%) and antimicrobial activity against Staphylococcus aureus and
Candida albicans. Dragon fruit formulation showed superior stability, whereas rose-based lipstick exhibited the highest
sensory acceptability. The findings suggest that natural pigment-based polyherbal lipsticks may serve as multifunctional
cosmetic products providing both aesthetic enhancement and therapeutic benefits.
Keywords :
Cheilitis, Herbal Lipstick, Natural Pigments, Beetroot, Dragon Fruit Peel, Rose Petals, Antioxidant Activity, Antimicrobial Activity.
References :
- Lugović-Mihić L, Blagec T, Japundžić I, Skroza N. Cheilitis: A comprehensive review. Acta Dermatovenerol Croat. 2018;26(2):136-142.
- Neville BW, Damm DD, Allen CM, Chi AC. Oral and Maxillofacial Pathology. 4th ed. St. Louis: Elsevier; 2016.
- Sharma PP. Cosmetics: Formulation, Manufacturing and Quality Control. 5th ed. New Delhi: Vandana Publications; 2018.
- Barel AO, Paye M, Maibach HI, editors. Handbook of Cosmetic Science and Technology. 4th ed. Boca Raton: CRC Press; 2014.
- Cai Y, Sun M, Corke H. Antioxidant activity of betalains from plants of the Amaranthaceae. J Agric Food Chem. 2003;51(8):2288-2294.
- Kanner J, Harel S, Granit R. Betalains as natural antioxidants. J Agric Food Chem. 2001;49(11):5178-5185.
- Nurliyana R, Syed ZI, Mustapha SK, Aisyah MR, Kamarul RK. Antioxidant study of pulps and peels of dragon fruits: A comparative study. Int Food Res J. 2010;17(2):367-375.
- Rebecca OPS, Boyce AN, Chandran S. Pigment identification and antioxidant properties of red dragon fruit (Hylocereus polyrhizus). Afr J Biotechnol. 2010;9(10):1450-1454.
- Kähkönen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS, et al. Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem. 1999;47(10):3954-3962.
- Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci. 2002;82(11):1336-1345.
- Subapriya R, Nagini S. Medicinal properties of neem leaves: A review. Curr Med Chem Anticancer Agents. 2005;5(2):149-156.
- Prabhu S, Jainu M, Devi CS. Antimicrobial activity of Piper betle leaf extracts against pathogenic microorganisms. J Ethnopharmacol. 2009;121(3):438-442.
- Arambewela LSR, Arawwawala LDAM, Ratnasooriya WD. Antidiabetic activities of aqueous and ethanolic extracts of Piper betle leaves. J Ethnopharmacol. 2005;102(2):239-245.
- Ali BH, Al-Wabel N, Blunden G. Phytochemical, pharmacological and toxicological aspects of Lawsonia inermis L.: A review. Phytother Res. 2008;22(11):1431-1437.
- Singh M, Kumar V. Wound healing activity of Lawsonia inermis leaf extracts. Int J Pharm Sci Res. 2011;2(5):1234-1238.
- Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate antioxidant activity. LWT Food Sci Technol. 1995;28(1):25-30.
Cheilitis is an inflammatory disorder of the lips characterized by dryness, fissuring, erythema, scaling, and
susceptibility to microbial infections. Conventional lip care products primarily provide cosmetic benefits and frequently
contain synthetic pigments that may induce allergic reactions and irritation. The present study aimed to develop and
comparatively evaluate natural pigment-enriched polyherbal therapeutic lipsticks intended for supportive management of
cheilitis. Three formulations were prepared using natural pigments obtained from dragon fruit peel, beetroot, and rose
petals along with neem oil, betel leaf extract, henna leaf extract, coconut oil, soy wax, vitamin E, and rose oil. Lipsticks
were prepared by the fusion molding method and evaluated for organoleptic characteristics, melting point, breaking
strength, spreadability, pH, homogeneity, skin irritation, stability, antioxidant activity, and antimicrobial activity. The
formulations exhibited satisfactory physicochemical properties and acceptable stability. Beetroot-based formulation
demonstrated the highest antioxidant activity (84.7 ± 1.5%) and antimicrobial activity against Staphylococcus aureus and
Candida albicans. Dragon fruit formulation showed superior stability, whereas rose-based lipstick exhibited the highest
sensory acceptability. The findings suggest that natural pigment-based polyherbal lipsticks may serve as multifunctional
cosmetic products providing both aesthetic enhancement and therapeutic benefits.
Keywords :
Cheilitis, Herbal Lipstick, Natural Pigments, Beetroot, Dragon Fruit Peel, Rose Petals, Antioxidant Activity, Antimicrobial Activity.