Authors :
Ibadin Ngozi Ogbenyalu; Okojie Rachael O; Ibadin Kennedy Osegua
Volume/Issue :
Volume 8 - 2023, Issue 12 - December
Google Scholar :
http://tinyurl.com/5f2ybpzy
Scribd :
http://tinyurl.com/mv6hfukz
DOI :
https://doi.org/10.5281/zenodo.10469508
Abstract :
Polycystic ovary Syndrome (PCOS) is a
heterogeneous endocrine disorder frequently used to
diagnosed women attending fertility clinics in Nigeria, it
is characterized by anovulation, hyperandrogenism and
polycystic ovary syndrome, several factors have been
associated with the pathophysiology of this disorder. The
ovarian follicle contains the follicular fluid (f.f) and is the
center of complex network of systemic and local
signaling pathways whereby follicle grows, and oocyte
acquires maturity, the Follicular fluid (f.f) contains
complex mixtures of steroids, metabolites, proteins
polysaccharides, small peptides, and antioxidants.
A prospective cross-sectional study was conducted
in four selected fertility clinics in South-South part of
Nigeria, the purposive sampling technique was used to
recruit participants in this study. A total of 206 women
were recruited, 101(49.1%) women fulfilled the
Rotterdam criteria for the diagnosis of Polycystic Ovary
Syndrome (PCOS), while 105 women (50.9%) without
PCOS were included as control. Immunological analysis
of cytokine levels was estimated using the Enzyme linked
Immunosorbent Assay (ELISA). Biochemical hyper-
androgenism as described as described by the
Rotterdam criteria was observed in 69(68%) of women
with PCOS, There was a statistically significant increase
in Follicular fluid (F.F) levels of IL-6,IL-18, and TNF-
alpha (8.616±1.037,50.409±6.068 and 27.014±3.252
respectively) in the PCOS group when compared to the
control group (6.777±0.815 and 48.172±5.799,
22.291±2.683), however, it was observed that IL-12
levels was lower in the PCOS group (2.144±0.258)
compared to the control group (2.212±0.266).The
present study was aimed to investigate Cytokines levels
in women with Polycystic Ovary Syndrome(PCOS)
attending Fertility clinics.
Keywords :
Cytokine, Follicular Fluid, Assisted Reproductive Treatment All correspondence to:
Polycystic ovary Syndrome (PCOS) is a
heterogeneous endocrine disorder frequently used to
diagnosed women attending fertility clinics in Nigeria, it
is characterized by anovulation, hyperandrogenism and
polycystic ovary syndrome, several factors have been
associated with the pathophysiology of this disorder. The
ovarian follicle contains the follicular fluid (f.f) and is the
center of complex network of systemic and local
signaling pathways whereby follicle grows, and oocyte
acquires maturity, the Follicular fluid (f.f) contains
complex mixtures of steroids, metabolites, proteins
polysaccharides, small peptides, and antioxidants.
A prospective cross-sectional study was conducted
in four selected fertility clinics in South-South part of
Nigeria, the purposive sampling technique was used to
recruit participants in this study. A total of 206 women
were recruited, 101(49.1%) women fulfilled the
Rotterdam criteria for the diagnosis of Polycystic Ovary
Syndrome (PCOS), while 105 women (50.9%) without
PCOS were included as control. Immunological analysis
of cytokine levels was estimated using the Enzyme linked
Immunosorbent Assay (ELISA). Biochemical hyper-
androgenism as described as described by the
Rotterdam criteria was observed in 69(68%) of women
with PCOS, There was a statistically significant increase
in Follicular fluid (F.F) levels of IL-6,IL-18, and TNF-
alpha (8.616±1.037,50.409±6.068 and 27.014±3.252
respectively) in the PCOS group when compared to the
control group (6.777±0.815 and 48.172±5.799,
22.291±2.683), however, it was observed that IL-12
levels was lower in the PCOS group (2.144±0.258)
compared to the control group (2.212±0.266).The
present study was aimed to investigate Cytokines levels
in women with Polycystic Ovary Syndrome(PCOS)
attending Fertility clinics.
Keywords :
Cytokine, Follicular Fluid, Assisted Reproductive Treatment All correspondence to:
