Oral aspirin treatment in the secondary
prevention of heart and cerebral vascular disease is well
known. However, oral administration can cause damage
to the gastrointestinal mucosa until bleeding occurs.
These problems can be overcome by development of
transdermal drug delivery system. The objective of this
study was to develop and evaluate the transdermal
patches of aspirin.Giving aspirin by transdermal patch
with matrix type to increase the antithrombotic
efficiency of aspirin. The principle of making
transdermal patches by solvent evaporation with aspirin
and polymer such as Eudragit RS 100, Eudragit RL 100,
Ethyl Cellulose, Polyvinyl pyrrolidone, and
Polyvinylacetate. The prepared formulations were
uniform in their physical characteristics. The
formulation F1-F4, combination of polymer (Eudragit
RL 100 :EudragitRS 100) showed better performance.
The results specify that aspirin transdermal patch can be
designed for obtaining better therapeutic benefits.
Keywords : Aspirin; Polymers; Eudragit; Ethyl Cellulose; Polyvinyl pyrrolidone; Polyvinylacetate.