Deep Learning-Based Liver Histopathology Image Classification: State-of-the-Art Techniques and Emerging Trends


Authors : E Pavan Kumar; Habibur Rahaman; Chityala Vishnuvardhan Reddy; Rokkam Sahil; Dr. Shwetha Buchanalli; Bharani Kumar Depuru

Volume/Issue : Volume 9 - 2024, Issue 6 - June


Google Scholar : https://tinyurl.com/ycshs7t3

Scribd : https://tinyurl.com/26wxjwse

DOI : https://doi.org/10.38124/ijisrt/IJISRT24JUN1368

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : This research investigates the application of deep learning techniques to enhance the diagnostic accuracy of liver tumour classification in collaboration with a prominent hospital in South India. By leveraging a carefully curated dataset of histopathological images, we evaluated the performance of several advanced deep learning architectures, including DenseNet 121, ResNet50, and VGG16. Our findings reveal that DenseNet121 outperformed the other models, achieving the highest accuracy in both training and testing phases, thus exceeding our predefined accuracy benchmarks. The superior performance of DenseNet121 is attributed to its dense connectivity, which facilitates improved feature and gradient propagation throughout the network. This study highlights the significant potential of AI-driven diagnostics in enhancing liver tumour classification, thereby optimizing the diagnostic workflow and providing substantial benefits for patient care and healthcare system efficiency.

Keywords : Deep Learning Models, Classification, Cholangiocarcinoma (CC), Hepatocellular Carcinoma (HCC).

References :

  1. Chen, M., Zhang, B., Topatana, W. et al. Classification and mutation prediction based on histopathology H&E images in liver cancer using deep learning. npj Precis. Onc. 4, 14 (2020). https://doi.org/10.1038/s41698-020-0120-3
  2. Kiani, A., Uyumazturk, B., Rajpurkar, P. et al. Impact of a deep learning assistant on the histopathologic classification of liver cancer. npj Digit. Med. 3, 23 (2020). https://doi.org/10.1038/ s41746-020-0232-8Classification of multi-differentiated liver cancer pathological images based on deep learning attention
  3. Chen, C., Chen, C., Ma, M. et al. Classification of multi-differentiated liver cancer pathological images based on deep learning attention mechanism. BMC Med Inform Decis Mak 22, 176 (2022). https://doi.org/10.1186/s12911-022-01919-1
  4. Y. -S. Lin, P. -H. Huang and Y. -Y. Chen, "Deep Learning-Based Hepatocellular Carcinoma Histopathology Image Classification: Accuracy Versus Training Dataset Size," in IEEE Access, vol. 9, pp. 33144-33157, 2021, doi: 10.1109/ACCESS. 2021.3060765
  5. Du, L., Yuan, J., Gan, M. et al. A comparative study between deep learning and radiomics models in grading liver tumors using hepatobiliary phase contrast-enhanced MR images. BMC Med Imaging 22, 218 (2022). https://doi.org/10.1186/s12880-022-00946-8
  6. Sailer, Maria, Schil ler, Florian, Falk, Thorsten, Jud, Andreas, Arke Lang, Sven, Ruf, Juri and Mix, Michael. "Prediction of the histopathological tumor type of newly diagnosed liver lesions from standard abdominal computer tomography with a machine-learning classifier based on convolutional neural networks" Current Directions in Biomedical Engineering, vol. 7, no. 1, 2021, pp. 150-153. https://doi.org/10.1515/cdbme-2021-1032
  7. Dong, X., Li, M., Zhou, P. et al. Fusing pre-trained convolutional neural networks features for multi-differentiated subtypes of liver cancer on histopathological images. BMC Med Inform Decis Mak 22, 122 (2022). https://doi.org/10.1186/s12911-022-01798-6
  8. Chen, W.-M., Fu, M., Zhang, C.-J., Xing, Q.-Q., Zhou, F., Lin, M.-J., Dong, X., Huang, J., Lin, S., Hong, M.-Z., Zheng, Q.-Z., & Pan, J.-S. (2022). Deep Learning-Based Universal Expert-Level Recognizing Pathological Images of Hepatocellular Carcinoma and Beyond. Frontiers in Medicine, 9, 853261. https://doi.org/10.3389/fmed.2022.853261
  9. Bhaskar, Nuthanakanti & Sasi Kiran, Jangala & Satyanarayan, Suma & Divya, Gaddam & Raju, Srujan & Kanthi, Murali & Patra, Raj. (2024). An approach for liver cancer detection from histopathology images using hybrid pre-trained models. TELKOMNIKA (Telecommunication Computing Electronics and Control). 22. 401-412. 10.12928/TELKOMNIKA.v22i2.25588.
  10. Kavitha, V.R., Hussain, F.B.J., Chillakuru, P., Shanmugam, P. (2024). Automated classification of liver cancer stages using deep learning on histopathological images. Traitement du Signal, Vol. 41, No. 1, pp. 373-381. https://doi.org/10.18280/ts. 410131
  11. Sridhar K, C K, Lai W-C, Kavin BP. Detection of Liver Tumour Using Deep Learning Based Segmentation with Coot Extreme Learning Model. Biomedicines. 2023; 11(3):800. https://doi.org/10. 3390/biomedicines11030800
  12. Rahman H, Bukht TFN, Imran A, Tariq J, Tu S, Alzahrani A. A Deep Learning Approach for Liver and Tumor Segmentation in CT Images Using ResUNet. Bioengineering (Basel). 2022;9(8):368. Published 2022 Aug 5. doi:10.3390/bioengineering 9080368
  13. C. Sun, A. Xu, D. Liu, Z. Xiong, F. Zhao and W. Ding, "Deep Learning-Based Classification of Liver Cancer Histopathology Images Using Only Global Labels," in IEEE Journal of Biomedical and Health Informatics, vol. 24, no. 6, pp. 1643-1651, June 2020, doi: 10.1109/JBHI.2019.2949837.
  14.  da Nóbrega, R.V.M., Rebouças Filho, P.P., Rodrigues, M.B. et al. Lung nodule malignancy classification in chest computed tomography images using transfer learning and convolutional neural networks. Neural Comput & Applic 32, 11065–11082 (2020). https://doi.org/10.1007/s00521-018-3895-1
  15. Albelwi, Saleh. (2022). Deep Architecture based on DenseNet-121 Model for Weather Image Recognition. International Journal of Advanced Computer Science and Applications. 13. 10.14569/ IJACSA.2022.0131065.
  16. Tammina, Srikanth. (2019). Transfer learning using VGG-16 with Deep Convolutional Neural Network for     Classifying Images. International Journal of Scientific and Research Publications (IJSRP). 9. p9420. 10.29322/IJSRP.9.10.2019.p9420.
  17. Liang, Jiazhi. (2020). Image classification based on RESNET. Journal of Physics: Conference Series. 1634. 012110. 10.1088/1742-6596/1634/1/012110
  18. Li X, Shen X, Zhou Y, Wang X, Li T-Q (2020) Classification of breast cancer histopathological images using interleaved DenseNet with SENet (IDSNet). PLoS ONE 15(5): e0232127. https:// doi.org/10.1371/journal. pone.0232127
  19. Qiu C, Wang X, Batson SA, Wang B, Casiano CA, Francia G, Zhang J-Y. A Luminex Approach to Develop an Anti-Tumor-Associated Antigen Autoantibody Panel for the Detection of Prostate Cancer in Racially/Ethnically Diverse Populations. Cancers. 2023; 15(16):4064. https://doi.org/10.3390/ cancers15164064

This research investigates the application of deep learning techniques to enhance the diagnostic accuracy of liver tumour classification in collaboration with a prominent hospital in South India. By leveraging a carefully curated dataset of histopathological images, we evaluated the performance of several advanced deep learning architectures, including DenseNet 121, ResNet50, and VGG16. Our findings reveal that DenseNet121 outperformed the other models, achieving the highest accuracy in both training and testing phases, thus exceeding our predefined accuracy benchmarks. The superior performance of DenseNet121 is attributed to its dense connectivity, which facilitates improved feature and gradient propagation throughout the network. This study highlights the significant potential of AI-driven diagnostics in enhancing liver tumour classification, thereby optimizing the diagnostic workflow and providing substantial benefits for patient care and healthcare system efficiency.

Keywords : Deep Learning Models, Classification, Cholangiocarcinoma (CC), Hepatocellular Carcinoma (HCC).

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