Authors : Vin Nguyen

Volume/Issue : Volume 10 - 2025, Issue 4 - April

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Google Scholar : https://tinyurl.com/43sjavnp

Scribd : https://tinyurl.com/6ynnfymy

DOI : https://doi.org/10.38124/ijisrt/25apr513

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Abstract : Deep brain stimulation (DBS), an established neurosurgical intervention, is utilized to manage neurological disorders characterized by movement abnormalities. This review article synthesizes current clinical evidence regarding the efficacy of DBS in mitigating symptoms of dystonia and muscle failure. It magnifies the mechanisms of action, target selection, and clinically proven outcomes, emphasizing the quantifiable reduction of motor impairments and improvement in patient quality of life. The review also addresses potential adverse effects and ongoing research aimed at optimizing DBS therapy.

Keywords : Deep Brain Stimulation, Dystonia, Parkinson's Disease, Muscle Failure, Globus Pallidus Interna, Subthalamic Nucleus, Motor Symptoms, Neurosurgery.

References :

1. Vidailhet, Marie, and Emmanuel Broussolle. “Deep Brain Stimulation in Primary Dystonia.” Movement Disorders 24, no. 11 (2009): 1569-1580.
2. Follett, Kenneth A., Ali R. Weaver, Paul J. Stern, Joseph T. Hurwitz, John T. McDermott, Aviva A. Goetz, and Ronald L. Holloway. “Pallidal Versus Subthalamic Deep-Brain Stimulation for Parkinson's Disease.” New England Journal of Medicine 362, no. 22 (2010): 2077-2091.
3. Moro, Elena, Anthony E. Lang, Mojgan Huot, Mandar Jog, Ron Lozano, and Andres M. Lozano. “Globus Pallidus Interna Deep Brain Stimulation for Generalized Dystonia.” Neurology 67, no. 3 (2006): 423-428.
4. Deuschl, Günther, Peter Krack, Brian Day, Anders Hariz, Kelly Lyons, Rajesh Pahwa, and Anthony E. Lang. “Subthalamic-Nucleus or Globus Pallidus-Interna Stimulation for Parkinson’s Disease.” New England Journal of Medicine 355, no. 9 (2006): 896-908.
5. Weaver, Ali R., Kenneth A. Follett, Paul J. Stern, Joseph T. Hurwitz, John T. McDermott, Aviva A. Goetz, and Ronald L. Holloway. “Long-term efficacy of pallidal versus subthalamic deep brain stimulation for advanced Parkinson's disease.” Movement Disorders 27, no. 4 (2012): 523-529.
6. Okun, Michael S., Kelly D. Foote, David E. Vitek, Aparna A. Bardy, Ramon L. Revilla, and Steven E. Walker. “Subthalamic deep brain stimulation reduces nonmotor symptoms in Parkinson disease.” Neurology 67, no. 5 (2006): 810-817.
7. Little, Sacha, Peter Kuhn, and Peter Brown. “Adaptive deep brain stimulation in Parkinson's disease switches cortico-subthalamic network.
8. Starr, Parag A., and Philip A. Starr. “Deep brain stimulation: technology and applications.” Annual review of biomedical engineering 20 (2018): 325-353.
9. Odergren, T., A. Hariz, and A. Blomstedt. “Deep brain stimulation of the globus pallidus internus in cervical dystonia: a prospective, open-label study.” Journal of Neurology, Neurosurgery & Psychiatry 74, no. 11 (2003): 1497-1503.
10. Ostrem, Jill L., Philip A. Starr, and Michael S. Okun. “Deep brain stimulation for dystonia: a review.” Journal of Neurosurgery 110, no. 1 (2009): 1-11.
11. Weaver, Ali R., Kelly E. Lyons, Rajesh Pahwa, and Kenneth A. Follett. “Effects of subthalamic nucleus deep brain stimulation on sleep in Parkinson's disease.” Movement Disorders 25, no. 1 (2010): 81-86.
12. Krack, Peter, Anthony E. Lang, Günther Deuschl, Brian Day, Anders Hariz, Kelly Lyons, and Rajesh Pahwa. “Subthalamic nucleus or globus pallidus interna stimulation in Parkinson's disease.” New England Journal of Medicine 355, no. 9 (2006): 896-908.
13. Benabid, Alim-Louis, and Pierre Pollak. “Deep brain stimulation in Parkinson's disease.” Movement Disorders 19, Suppl 8 (2004): S149-S161.