Authors :
Kashif Abbas; Dr. Mudassir Alam; Tanjeem Raza; S Mohd Hasan Abedi
Volume/Issue :
Volume 8 - 2023, Issue 7 - July
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/mn5xxw9a
DOI :
https://doi.org/10.5281/zenodo.8262690
Abstract :
Androgenetic alopecia (AGA) is a condition
that affects both men and women who are genetically
predisposed, resulting in a recognizable pattern of hair
follicle shrinkage without scarring.The root cause of this
condition can be linked to the action of the enzyme 5-
alpha-reductase, responsible for converting testosterone
into dihydrotestosterone (DHT), a more potent
androgen. The accumulation of DHT in hair follicles
ultimately leads to hair loss. The primary approach to
treating AGA involves targeting the inhibition of 5-
alpha-reductase. A recent trend in natural remedies
involves the use of pumpkin seed for AGA treatment. In
this study, the focus is on conducting virtual simulations
and ADME/T (Absorption, Distribution, Metabolism,
Excretion/Toxicity) analysis of active compounds found
in pumpkin seed. The objective is to assess their
interactions with the 5-alpha-reductase enzyme and
visualize these interactions. This research aims to
provide insights into the potential effectiveness of
pumpkin seed as a therapeutic option for AGA, through
computational evaluations of protein-ligand interactions.
Keywords :
Androgenetic Alopecia, DHT, Finasteride, Pumpkin Seed, 5-Alpha Reductase.
Androgenetic alopecia (AGA) is a condition
that affects both men and women who are genetically
predisposed, resulting in a recognizable pattern of hair
follicle shrinkage without scarring.The root cause of this
condition can be linked to the action of the enzyme 5-
alpha-reductase, responsible for converting testosterone
into dihydrotestosterone (DHT), a more potent
androgen. The accumulation of DHT in hair follicles
ultimately leads to hair loss. The primary approach to
treating AGA involves targeting the inhibition of 5-
alpha-reductase. A recent trend in natural remedies
involves the use of pumpkin seed for AGA treatment. In
this study, the focus is on conducting virtual simulations
and ADME/T (Absorption, Distribution, Metabolism,
Excretion/Toxicity) analysis of active compounds found
in pumpkin seed. The objective is to assess their
interactions with the 5-alpha-reductase enzyme and
visualize these interactions. This research aims to
provide insights into the potential effectiveness of
pumpkin seed as a therapeutic option for AGA, through
computational evaluations of protein-ligand interactions.
Keywords :
Androgenetic Alopecia, DHT, Finasteride, Pumpkin Seed, 5-Alpha Reductase.
