Authors :
SWETHA K
Volume/Issue :
Volume 7 - 2022, Issue 9 - September
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3ywUbkz
DOI :
https://doi.org/10.5281/zenodo.7192144
Abstract :
New diseases and germs are emerging day by
day in our world. But cancer is the most deadly disease
that came many years. It is very sad that it could not be
eradicated permanently till today. Cancer is caused by
abnormal cell growth. As a result it is impossible to save
the victim. So it is a life-killing disease. But many
scientists are still struggling to find a cure for it. And
many types of plants, fruits, vegetables are being
researched to use the chemicals against cancer. In this
study, explain the anticancer properties of a plant family
known as Cucurbitacins. Estrogen signaling is crucial
for carcinoma initiation and progression which
stimulates estrogen receptor (ER) for proliferation
leading to growth of estrogen-responsive tumors. Plant
compounds like coumarins, cucurbitacins, flavonoids,
alkaloids and flavonoids, etc...From different plant parts
were used because the further alternative treatment of
breast cancer. Among the compounds, cucurbitacins
have shown promising results over the treatment.
Cucurbitacins is a highly oxygenated tetracyclic
triterpenoids species. These include the blockers of the
JAK/STAT pathways. Now explain the chemical
structure, physical properties, and the role of in vitro, in
vivo, along with the in silico analysis shows that the
estrogen receptor controls the proliferation of breast
cancer cells.
Keywords :
Cancer, Estrogen receptor, Cucurbitacins, JAK/STAT, MAPK and Proliferation.
New diseases and germs are emerging day by
day in our world. But cancer is the most deadly disease
that came many years. It is very sad that it could not be
eradicated permanently till today. Cancer is caused by
abnormal cell growth. As a result it is impossible to save
the victim. So it is a life-killing disease. But many
scientists are still struggling to find a cure for it. And
many types of plants, fruits, vegetables are being
researched to use the chemicals against cancer. In this
study, explain the anticancer properties of a plant family
known as Cucurbitacins. Estrogen signaling is crucial
for carcinoma initiation and progression which
stimulates estrogen receptor (ER) for proliferation
leading to growth of estrogen-responsive tumors. Plant
compounds like coumarins, cucurbitacins, flavonoids,
alkaloids and flavonoids, etc...From different plant parts
were used because the further alternative treatment of
breast cancer. Among the compounds, cucurbitacins
have shown promising results over the treatment.
Cucurbitacins is a highly oxygenated tetracyclic
triterpenoids species. These include the blockers of the
JAK/STAT pathways. Now explain the chemical
structure, physical properties, and the role of in vitro, in
vivo, along with the in silico analysis shows that the
estrogen receptor controls the proliferation of breast
cancer cells.
Keywords :
Cancer, Estrogen receptor, Cucurbitacins, JAK/STAT, MAPK and Proliferation.
