Authors : Priyam Sharma; Vineet Kumar Singh; Pushpendra Kannojia

Volume/Issue : Volume 11 - 2026, Issue 5 - May

Google Scholar : https://tinyurl.com/3t5y5y9v

Scribd : https://tinyurl.com/yc4kf263

DOI : https://doi.org/10.38124/ijisrt/26May1943

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : The genus Crassula (family Crassulaceae) contains about 150-200 species of succulent plants that are mainly found in southern Africa, but are also well represented in Europe, the Americas, Australia and New Zealand. Although probably cultivated most famously as houseplants these species have a long history of traditional medicine use by indigenous African peoples and in Asian herbal medicine, where they have been used to treat gastrointestinal illness, epilepsy, diabetes, wounds, skin burns, inflammation, and infections. This review is a comprehensive synthesis of the existing information on the phytochemical composition, pharmacological activities, toxicological profile, and future therapeutic potential of the genus Crassula. Phytochemical studies have shown a wide range of bioactive secondary metabolites, such as phenolic acids (gallic, caffeic, ferulic, chlorogenic acids), flavonoids (quercetin, kaempferol, apigenin, naringenin, catechin), terpenoids, phytosterols (-sitosterol), C-glucosides (ber Pharmacological studies have validated many traditional uses, demonstrating .

Keywords : Crassula; Crassulaceae; Phytochemistry; Pharmacology; Bergenin; Traditional Medicine; Antimicrobial; Antioxidant; Antidiabetic; Anticancer; Hepatoprotective; Crassula ovata; Jade Plant

References :

1. Vikhe SR, Gholap SA, Fulsundar AS, et al. Preliminary phytochemical screening of various extracts of jade (Crassula ovata) plant in India. World J. Biol. Pharm. Health Sci. 2024;17:303-9.doi:https://doi.org/10.30574/wjbphs.2024.17.3.0106
2. Kumar S, Choudhury T, Kumar R, et al. A Review on Discovering the Satisfying Potentials of Crassula Ovata: From Modern Usages to Medication Presentations. International Journal of Science and Technology (IJST). 2025;2(3):36-46.doi:https://doi.org/10.70558/IJST.2025.v2.i3.241077.
3. Hassan MH, Elwekeel A, Moawad A, et al. Phytochemical constituents and biological activity of selected genera of family Crassulaceae: A review. South African Journal of Botany. 2021;141:383-404.doi:https://doi.org/10.1016/j.sajb.2021.05.016
4. Ding H, Han S, Ye Y, et al. Ten plastomes of Crassula (Crassulaceae) and phylogenetic implications. Biology. 2022;11(12):1779.doi:https://doi.org/10.3390/biology11121779
5. Gehrig H, Gaußmann O, Marx H, et al. Molecular phylogeny of the genus Kalanchoe (Crassulaceae) inferred from nucleotide sequences of the ITS-1 and ITS-2 regions. Plant Science. 2001;160(5):827-35.doi:https://doi.org/10.1016/S0168-9452(00)00447-7
6. Deepthi N, Sai Deepika L, Asif S, et al. From jade to health: a holistic review of Crassula phytochemistry and pharmacology. European Journal of Biomedical. 2024;11(4):111-5.doi:
7. Zhang J-Q, Meng S-Y, Allen GA, et al. Rapid radiation and dispersal out of the Qinghai-Tibetan Plateau of an alpine plant lineage Rhodiola (Crassulaceae). Molecular phylogenetics and evolution. 2014;77:147-58.doi:https://doi.org/10.1016/j.ympev.2014.04.013
8. Park KT, Son O. Complete chloroplast genome of Crassula aquatica: Comparative genomic analysis and phylogenetic relationships. Genes. 2024;15(11):1399.doi:https://doi.org/10.3390/genes15111399
9. Johnson S, Ellis A, Carrick P, et al. Moth pollination and rhythms of advertisement and reward in Crassula fascicularis (Crassulaceae). South African Journal of Botany. 1993;59(5):511-3.doi:https://doi.org/10.1016/S0254-6299(16)30696-2
10. Fradera‐Soler M, Mravec J, Harholt J, et al. Cell wall polysaccharide and glycoprotein content tracks growth‐form diversity and an aridity gradient in the leaf‐succulent genus Crassula. Physiologia Plantarum. 2023;175(5):e14007.doi:https://doi.org/10.1111/ppl.14007
11. Raslan MA, Abdel-Rahman RF, Fayed HM, et al. Unveiling phytoconstituents and the anti-inflammatory potential of Crassula tetragona L. in ulcerative colitis: A focus on the PPARγ/SIRT1 axis. Inflammopharmacology. 2026;34(1):707-27.doi:https://doi.org/10.1007/s10787-025-02049-6
12. Ghouri YA, Tahan V, Shen B. Secondary causes of inflammatory bowel diseases. World journal of gastroenterology. 2020;26(28):3998.doi:https://doi.org/10.3748/wjg.v26.i28.3998
13. Fradera‐Soler M, Mravec J, Schulz A, et al. Revisiting an ecophysiological oddity: Hydathode‐mediated foliar water uptake in Crassula species from southern Africa. Plant, Cell & Environment. 2024;47(2):460-81.doi:https://doi.org/10.1111/pce.14743
14. Ferrat M, Moulahoum H, Boumaza BMA, et al. Gadolinium chloride attenuates acetic acid-evoked colitis in mice by reducing neutrophil infiltration and pro-oxidative enzyme activity. Naunyn-Schmiedeberg's Archives of Pharmacology. 2019;392(3):299-311.doi:https://doi.org/10.1007/s00210-018-1592-3
15. Chevé-Kools E, Gentelet F, Morais Fernandes J, et al. Nitrogen-containing metabolites in the Crassulaceae family: structures, biological activities, occurrence and phylogeny. Phytochemistry Reviews. 2025:1-23.doi:https://doi.org/10.1007/s11101-025-10139-0
16. Modise N, Cozien R, Jordaens K, et al. Short-tongued fly pollination of the vomit-scented Crassula peploides (Crassulaceae) in the southern African Drakensberg Mountains. South African Journal of Botany. 2025;183:218-28.doi:https://doi.org/10.1016/j.sajb.2025.05.016
17. Smith GF. The Invasive Kalanchoe× houghtonii (Crassulaceae Subfam. Cotyledonoideae) Confirmed as Occurring in South Africa. Haseltonia. 2026;33(1):1-7.doi:https://doi.org/10.2985/026.033.0102
18. Rodewald SE, Klein D-P, Shtein R, et al. A new phylogenetic framework for the genus Kalanchoe (Crassulaceae) and implications for infrageneric classification. Annals of Botany. 2025;135(7):1311-28.doi:https://doi.org/10.1093/aob/mcaf004
19. AlSedairy SA, Binobead MA, Alanazi F, et al. Evaluation of the Antibacterial, Antioxidant, Anticancer, and Antidiabetic Activities of the Leaves and Inflorescences of Crassula capitella. Biomedicines. 2026;14(1):121.doi:https://doi.org/10.3390/biomedicines14010121
20. Matimati I, Moyo M. Responses to warming and low soil moisture provide insights into vulnerability of key plant species of Southern Africa. Plant Ecology. 2026;227(4):43.doi:https://doi.org/10.1007/s11258-026-01604-7
21. Bruyns P, Hanáček P, Klak C. Crassula, insights into an old, arid-adapted group of southern African leaf-succulents. Molecular phylogenetics and evolution. 2019;131:35-47.doi:https://doi.org/10.1016/j.ympev.2018.10.045
22. Satheeshkumar N. HISTOPATHOLOGICAL EVIDENCE OF NEUROPROTECTION BY CRASSULA OVATA IN PTZ-INDUCED SEIZURE MODEL IN ALBINO RATS. World. 2026;5(2).doi:
23. Carrera C, Ruiz-Rodríguez A, Palma M, et al. Ultrasound assisted extraction of phenolic compounds from grapes. Analytica chimica acta. 2012;732:100-4.doi:https://doi.org/10.1016/j.aca.2011.11.032
24. Diatta K, Diatta W, Fall AD, et al. Ethno apicultural survey of Melliferous plant species in the great Green Wall Widou and Koyli alpha, Senegal. Asian Plant Res. J. 2019;3(1):1-9.doi:10.9734/APRJ/2019/v3i130060
25. El-Hawary SS, Mohammed R, Abouzid S, et al. Anti-arthritic activity of 11-O-(4′-O-methyl galloyl)-bergenin and Crassula capitella extract in rats. Journal of Pharmacy and Pharmacology. 2016;68(6):834-44.doi:https://doi.org/10.1111/jphp.12566
26. Eid O, Gonaid M. Crassulaceae (chemistry and pharmacology)-A review. Future Journal of Pharmaceutical Sciences. 2018;4(2):234-40.doi:https://doi.org/10.1016/j.fjps.2018.07.003
27. Muiruri MD, Mwangi W. Phytochemical and antimicrobial activity of (Crassula ovata) jade plant on different strains of bacteria. 2015.doi:10.9734/EJMP/2016/19753
28. Kandeda AK, Mezui C, Kengni S, et al. Kalanchoe crenata Haw.(Crassulacea) Decreases Hippocampal Neuron Loss and Improves Memory and Executive Function in Aged Rats: Implications for Anti‐Inflammatory and Antioxidant Mechanisms. Brain and Behavior. 2025;15(2):e70261.doi:https://doi.org/10.1002/brb3.70261
29. López-Angulo G, Montes-Avila J, Díaz-Camacho SP, et al. Comparison of terpene and phenolic profiles of three wild species of Echeveria (Crassulaceae). J Appl Bot Food Qual. 2018;91:145-54.doi:10.5073/JABFQ.2018.091.020
30. Liu K, Zhang X, Xie L, et al. Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy. Pharmacological research. 2021;164:105373.doi:https://doi.org/10.1016/j.phrs.2020.105373
31. Bakrim S, Benkhaira N, Bourais I, et al. Health benefits and pharmacological properties of stigmasterol. Antioxidants. 2022;11(10):1912.doi:https://doi.org/10.3390/antiox11101912
32. Adepoju FO, Duru KC, Li E, et al. Pharmacological potential of betulin as a multitarget compound. Biomolecules. 2023;13(7):1105.doi:https://doi.org/10.3390/biom13071105
33. Mbhele N, Ncube B, Ndhlala A, et al. Pro-inflammatory enzyme inhibition and antioxidant activity of six scientifically unexplored indigenous plants traditionally used in South Africa to treat wounds. South African Journal of Botany. 2022;147:119-29.doi:https://doi.org/10.1016/j.sajb.2021.12.026
34. Ogburn RM, Edwards EJ. Repeated origin of three-dimensional leaf venation releases constraints on the evolution of succulence in plants. Current biology. 2013;23(8):722-6.doi:https://doi.org/10.1016/j.cub.2013.03.029
35. VIKHE S, GHOLAP S, VIKHE R. ANTIDIABETIC, ANTIHYPERLIPIDEMIC EFFECTS AND QUANTIFICATION OF BIOACTIVE COMPOUNDS BY HPLC FROM CRASSULA OVATA LEAVES EXTRACTS ON STREPTOZOTOCIN INDUCED DIABETIC WISTAR RATS. INTERNATIONAL JOURNAL OF AYURVEDIC MEDICINE. 2024;15(3):757-64.doi:
36. Moteetee A, Nagendran C. Comparative anatomical studies in five southern African species of Crassula: II. Structure of the leaf and the occurrence of transfer cells. South African Journal of Botany. 1997;63(2):95-9.doi:https://doi.org/10.1016/S0254-6299(15)30709-2
37. Amabeoku GJ, Mbamalu ON, Davids T, et al. Evaluation of the anticonvulsant activity of the leaf methanol extract of Crassula arborescens (Mill.) Willd.(Crassulaceae) in mice. Journal of Pharmacy and Pharmacology. 2014;2:393-403.doi:
38. Ambriz-Pérez DL, Leyva-López N, Gutierrez-Grijalva EP, et al. Phenolic compounds: Natural alternative in inflammation treatment. A Review. Cogent Food & Agriculture. 2016;2(1):1131412.doi:https://doi.org/10.1080/23311932.2015.1131412
39. Azeem M, Hanif M, Mahmood K, et al. An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: A review. Polymer Bulletin. 2023;80(1):241-62.doi:https://doi.org/10.1007/s00289-022-04091-8
40. Baranwal A, Aggarwal P, Rai A, et al. Pharmacological actions and underlying mechanisms of catechin: A review. Mini Reviews in Medicinal Chemistry. 2022;22(5):821-33.doi:https://doi.org/10.2174/1389557521666210902162120
41. Bezerra GB, de Souza LdM, Dos Santos AS, et al. Hydroalcoholic extract of Brazilian red propolis exerts protective effects on acetic acid-induced ulcerative colitis in a rodent model. Biomedicine & Pharmacotherapy. 2017;85:687-96.doi:https://doi.org/10.1016/j.biopha.2016.11.080
42. Baima G, Muwalla M, Testa G, et al. Periodontitis prevalence and severity in inflammatory bowel disease: A case–control study. Journal of periodontology. 2023;94(3):313-22.doi:https://doi.org/10.1002/JPER.22-0322
43. Buranasudja V, Muangnoi C, Sanookpan K, et al. Eriodictyol attenuates H2O2-induced oxidative damage in human dermal fibroblasts through enhanced capacity of antioxidant machinery. Nutrients. 2022;14(12):2553.doi:https://doi.org/10.3390/nu14122553
44. Caruso R, Marafini I, Franzè E, et al. Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut. Mucosal immunology. 2014;7(6):1467-79.doi:https://doi.org/10.1038/mi.2014.35
45. Chokhone K, Talukdar N, Sarma MP, et al. Screening of phytochemicals and evaluation of anti-microbial, anti-oxidant and in-vitro antidiabetic activity of crassula ovata leaves. International Journal of Pharmaceutical Sciences and Research. 2017;8(2):859.doi:http://dx.doi.org/10.13040/IJPSR.0975-8232.8
46. Al-Yassery HK, Kadhim EJ. Cytotoxic effects of the Crassula ovata n-hexane fraction on human esophagus cancer KYSE-30 cells. Review of Clinical Pharmacology and Pharmacokinetics–International Edition. 2024;38(s2):97-100.doi:https://doi.org/10.61873/jmob1139
47. Al-Yassery HK, Kadhim EJ. Isolation and characterization of a tetrahydroprotoberberine alkaloid from Crassula ovata. Review of Clinical Pharmacology and Pharmacokinetics–International Edition. 2024;38(s2):101-4.doi:https://pharmakonpress.gr/?p=20666&lang=en
48. Sk A, Deepthi N, Sai Deepika L, et al. Phytochemical screening and evaluation of antioxidant activity of Callisia repens and Crassula ovata: An in-vitro study. 2024.doi:https://doi.org/10.30574/wjbphs.2024.19.1.0377
49. Alberti Á, Riethmüller E, Béni S, et al. Evaluation of radical scavenging activity of Sempervivum tectorum and Corylus avellana extracts with different phenolic composition. Natural Product Communications. 2016;11(4):1934578X1601100412.doi:https://doi.org/10.1177/1934578X1601100412
50. Altavilla D, Polito F, Bitto A, et al. Anti-inflammatory effects of the methanol extract of Sedum telephium ssp. maximum in lipopolysaccharide-stimulated rat peritoneal macrophages. Pharmacology. 2008;82(4):250-6.doi:https://doi.org/10.1159/000157626
51. Kumar R, Tayade A, Chaurasia O, et al. Evaluation of anti-oxidant activities and total phenol and flavonoid content of the hydro-alcoholic extracts of Rhodiola sp. Pharmacognosy Journal. 2010;2(11):431-5.doi:https://doi.org/10.1016/S0975-3575(10)80027-6
52. Rana S, Sharma S, Prasad K, et al. Role of oxidative stress & antioxidant defence in ulcerative colitis patients from north India. Indian Journal of Medical Research. 2014;139(4):568-71.doi:
53. Tatsimo SJN, Tamokou JdD, Havyarimana L, et al. Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum. BMC Research notes. 2012;5(1):158.doi:https://doi.org/10.1186/1756-0500-5-158
54. Nwadinigwe AO. Antimicrobial activities of methanol and aqueous extracts of the stem of Bryophyllum pinnatum Kurz (Crassulaceae). African Journal of Biotechnology. 2011;10(72):16342-6.doi:https://doi.org/10.5897/ajb11.1000
55. Jadhav A, Kedia P, Aashmi PJ, et al. Phytochemical profiling, green synthesis of silver nanoparticles, and In silico validation of Crassula ovata for antimicrobial applications. Medicinal Plants-International Journal of Phytomedicines and Related Industries. 2025;17(3):573-83.doi:https://doi.org/10.5958/0975-6892.2025.00059.x
56. Pegnyemb DE, Mbing JN, de Théodore Atchadé A, et al. Antimicrobial biflavonoids from the aerial parts of Ouratea sulcata. Phytochemistry. 2005;66(16):1922-6.doi:https://doi.org/10.1016/j.phytochem.2005.06.017
57. Abbas A, Naqvi SAR, Rasool MH, et al. Phytochemical analysis, antioxidant and antimicrobial screening of Seriphidium oliverianum plant extracts. Dose-response. 2021;19(1):15593258211004739.doi:https://doi.org/10.1177/15593258211004739
58. Déciga‐Campos M, González‐Trujano ME, Ventura‐Martínez R, et al. Antihyperalgesic Activity of R hodiola r osea in a Diabetic Rat Model. Drug Development Research. 2016;77(1):29-36.doi:https://doi.org/10.1002/ddr.21289
59. Patil SB, Dongare VR, Kulkarni CR, et al. Antidiabetic activity of Kalanchoe pinnata in streptozotocin-induced diabetic rats by glucose independent insulin secretagogue action. Pharmaceutical biology. 2013;51(11):1411-8.doi:https://doi.org/10.3109/13880209.2013.794364
60. Zhang H, Tsao R. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Current Opinion in Food Science. 2016;8:33-42.doi:https://doi.org/10.1016/j.cofs.2016.02.002
61. Riccardi L, Mazzon E, Bruscoli S, et al. Peroxisome proliferator-activated receptor-α modulates the anti-inflammatory effect of glucocorticoids in a model of inflammatory bowel disease in mice. Shock. 2009;31(3):308-16.doi:10.1097/SHK.0b013e31818339e7
62. Kamboj A, Saluja AK. Isolation of stigmasterol and β-sitosterol from petroleum ether extract of aerial parts of Ageratum conyzoides (Asteraceae). Int. J. Pharm. Pharm. Sci. 2011;3(1):94-6.doi:
63. Lifta HK. Bergenin, Isolated Compound from Crassula ovata Plant, Its Role as Synergistic Effect With Docetaxel Against Prostatic Cancer (PC-3) Cell Lines. Iraqi Journal of Pharmaceutical Sciences. 2024;33(4SI)):111-8.doi:https://doi.org/10.31351/vol33iss(4SI)pp111-118
64. Kaewpiboon C, Srisuttee R, Malilas W, et al. Extract of Bryophyllum laetivirens reverses etoposide resistance in human lung A549 cancer cells by downregulation of NF-κB. Oncology reports. 2014;31(1):161-8.doi: https://doi.org/10.3892/or.2013.2844
65. Huang D, Zhang W, Huang D, et al. Antitumor activity of the aqueous extract from Sedum sarmentosum Bunge in vitro. Cancer Biotherapy and Radiopharmaceuticals. 2010;25(1):81-8.doi:https://doi.org/10.1089/cbr.2009.0632
66. Dighe SB, Bhawar SB, Yadav SS, et al. EFFECT OF CRASSULA OVATA PLANT EXTRACT ON CCL 4-INDUCED LIVER TOXICITY AND PENTOBARBITAL SLEEPING TIME IN RATS. Indian Drugs. 2025;62(11).doi:10.53879/id.62.11.15402
67. Ryu D-S, Lee H-S, Lee G-S, et al. Effects of the ethylacetate extract of Orostachys japonicus on induction of apoptosis through the p53-mediated signaling pathway in human gastric cancer cells. Biological and Pharmaceutical Bulletin. 2012;35(5):660-5.doi:https://doi.org/10.1248/bpb.35.660
68. Lee H-S, Lee G-S, Kim S-H, et al. Anti-oxidizing effect of the dichloromethane and hexane fractions from Orostachys japonicus in LPS-stimulated RAW 264.7 cells via upregulation of Nrf2 expression and activation of MAPK signaling pathway. BMB reports. 2014;47(2):98.doi:https://doi.org/10.5483/BMBRep.2014.47.2.088
69. Mahata S, Maru S, Shukla S, et al. Anticancer property of Bryophyllum pinnata (Lam.) Oken. leaf on human cervical cancer cells. BMC complementary and alternative medicine. 2012;12(1):15.doi:
70. Afzal M, Gupta G, Kazmi I, et al. Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum. Fitoterapia. 2012;83(5):853-8.doi:https://doi.org/10.1016/j.fitote.2012.03.013
71. Chaturvedi OS, Joshi A, Dubey BK. Pharmacognostical, phytochemical evaluation and antiinflammatory activity of stem of Kalanchoe pinnata Pers. Int J Pharm Sci Res. 2012;3(4):1133-40.doi:
72. Costa ACdO, Fernandes JM, Neto TdSN, et al. Quantification of chemical marker of Kalanchoe brasiliensis (Crassulaceae) leaves by HPLC–DAD. Journal of Liquid Chromatography & Related Technologies. 2015;38(7):795-800.doi:https://doi.org/10.1080/10826076.2014.971370
73. Costa SS, Corrêa MFP, Casanova LM. A new triglycosyl flavonoid isolated from leaf juice of Kalanchoe gastonis-bonnieri (Crassulaceae). Natural Product Communications. 2015;10(3):1934578X1501000314.doi:https://doi.org/10.1177/1934578X1501000314
74. Szewczyk K, Krzaczek T, Łopatyński T, et al. Flavonoids from Jovibarba globifera (Crassulaceae) rosette leaves and their antioxidant activity. Natural product research. 2014;28(19):1655-8.doi:https://doi.org/10.1080/14786419.2014.938335
75. Chen D, Fan J, Wang P, et al. Isolation, identification and antioxidative capacity of water-soluble phenylpropanoid compounds from Rhodiola crenulata. Food Chemistry. 2012;134(4):2126-33.doi:https://doi.org/10.1016/j.foodchem.2012.04.011