Authors :
Dr.Hina Baraiya; Dr. Hariom Sharma; Dr. Jagruti Dholakia; Dr. Sapna Patel
Volume/Issue :
Volume 7 - 2022, Issue 12 - December
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3QIn0Cs
DOI :
https://doi.org/10.5281/zenodo.7537944
Abstract :
The aim of the study was to estimate serum
amylase and serum cholinesterase levels in patients of acute
OP poisoning and to correlate serum amylase levels with
serum cholinesterase and outcome in term of mortality in
same patients.
Material and Methods: A prospective observational study
was conducted in 106 clinically proven cases of OP
poisoning attending the Emergency Department of Sir
Takhtsinhji General Hospital, Bhavnagar. Serum amylase
and Cholinesterase were measured on fully auto analyzer ILab at the time of admission. Patients were followed up for
final outcome.
Results: Serum cholinesterase levels were decreased in all
the three groups. Serum amylase was significantly elevated
in group III when compared to group I and II. Correlation
between serum cholinesterase levels and serum amylase
showed significant negative correlation. Mean value of
serum cholinesterase and serum amylase at the time of
admission in survivor were 1265±866.5 and 146±68.24
respectively while in non-survivor 756.4±741 and
417±138.6 respectively.
Conclusion: Acute OP poisoning is associated with
increased serum amylase levels and decreased serum ChE
levels. Serum cholinesterase inhibition & lt;10% and
hyper-amylasemia & gt;300 U/L has been associated with
high degree of mortality. Serum amylase estimation can be
used as
a prognostic indicator along with the serum cholinesterase
activity in assessing severity of OP poisoning. Further
studies with estimation of isoenzymes of amylase and
correlation with clinical severity in larger population is
necessary to know the type of hyperamylasemia and its
clinical significance in acute OP poisoning
Keywords :
Amylase, Cholinesterase, Organophosphorus poisoning.
The aim of the study was to estimate serum
amylase and serum cholinesterase levels in patients of acute
OP poisoning and to correlate serum amylase levels with
serum cholinesterase and outcome in term of mortality in
same patients.
Material and Methods: A prospective observational study
was conducted in 106 clinically proven cases of OP
poisoning attending the Emergency Department of Sir
Takhtsinhji General Hospital, Bhavnagar. Serum amylase
and Cholinesterase were measured on fully auto analyzer ILab at the time of admission. Patients were followed up for
final outcome.
Results: Serum cholinesterase levels were decreased in all
the three groups. Serum amylase was significantly elevated
in group III when compared to group I and II. Correlation
between serum cholinesterase levels and serum amylase
showed significant negative correlation. Mean value of
serum cholinesterase and serum amylase at the time of
admission in survivor were 1265±866.5 and 146±68.24
respectively while in non-survivor 756.4±741 and
417±138.6 respectively.
Conclusion: Acute OP poisoning is associated with
increased serum amylase levels and decreased serum ChE
levels. Serum cholinesterase inhibition & lt;10% and
hyper-amylasemia & gt;300 U/L has been associated with
high degree of mortality. Serum amylase estimation can be
used as
a prognostic indicator along with the serum cholinesterase
activity in assessing severity of OP poisoning. Further
studies with estimation of isoenzymes of amylase and
correlation with clinical severity in larger population is
necessary to know the type of hyperamylasemia and its
clinical significance in acute OP poisoning
Keywords :
Amylase, Cholinesterase, Organophosphorus poisoning.
