Authors :
Julius O Akhaine; Venyir M Ramyil; Nuhu K Dakum; Christian O Isichei; Samaila I Shuaibu; Chimaobi G Ofoha
Volume/Issue :
Volume 8 - 2023, Issue 9 - September
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/27xyds4u
DOI :
https://doi.org/10.5281/zenodo.8383265
Abstract :
Background
Cancer of the prostate (CaP) is the second most
commonly diagnosed cancer worldwide and the sixth
leading cause of death from cancer in males. . Black men
of African descent have higher risk for developing prostate
cancer and are most likely to present at a younger age
with more advanced disease and a poorer disease
prognosis.
Objective
To determine if there is a relationship between the
level of serum 25 hydroxy vitamin D and aggressiveness of
prostate cancer using the Gleason score in black Africans
in Jos.
Methods
A cross sectional study conducted among fifty
patients presenting at the urological surgical out-patient
clinics of the Jos University Teaching Hospital who were
evaluated to have a clinical diagnosis of prostate cancer
and scheduled for prostate biopsy. Blood samples for
serum 25-hydroxy vitamin D were assayed using the
ELISA technique, prostate biopsy was done and only those
histologically confirmed to be prostate cancer were
analysed. Data was collected using a proforma with
statistical analysis done using SPSS(R) version 23 and
Spearman’s rank correlation test used with a p-value <
0.05 considered significant.
Results
Fifty patients with histologically proven prostate
cancer was studied whose age ranged from 50-89 years
with a predominant age group 70-79 years (70.0±7.9).The
mean level of serum 25-hydroxy vitamin D was
37.90ng/ml±17.92. All patients in the study had
adenocarcinoma as the histologic type with a mean
Gleason score of 9.36±13.14. A Spearman’s rank order
correlation was statistically significant (rs (50) = -0.423, p =
0.002).
Conclusion
A Spearman’s rank order correlation shows a
moderate negative correlation between the serum 25-
hydroxy vitamin D and Gleason score (rs (50) = -0.423, p =
0.002.Thus, serum 25-hydroxy vitamin D assay can be used
to prognosticate in patients with cancer of the prostate.
Keywords :
Serum 25-Hydroxy Vitamin D, Prostate Cancer, Gleason Score
Background
Cancer of the prostate (CaP) is the second most
commonly diagnosed cancer worldwide and the sixth
leading cause of death from cancer in males. . Black men
of African descent have higher risk for developing prostate
cancer and are most likely to present at a younger age
with more advanced disease and a poorer disease
prognosis.
Objective
To determine if there is a relationship between the
level of serum 25 hydroxy vitamin D and aggressiveness of
prostate cancer using the Gleason score in black Africans
in Jos.
Methods
A cross sectional study conducted among fifty
patients presenting at the urological surgical out-patient
clinics of the Jos University Teaching Hospital who were
evaluated to have a clinical diagnosis of prostate cancer
and scheduled for prostate biopsy. Blood samples for
serum 25-hydroxy vitamin D were assayed using the
ELISA technique, prostate biopsy was done and only those
histologically confirmed to be prostate cancer were
analysed. Data was collected using a proforma with
statistical analysis done using SPSS(R) version 23 and
Spearman’s rank correlation test used with a p-value <
0.05 considered significant.
Results
Fifty patients with histologically proven prostate
cancer was studied whose age ranged from 50-89 years
with a predominant age group 70-79 years (70.0±7.9).The
mean level of serum 25-hydroxy vitamin D was
37.90ng/ml±17.92. All patients in the study had
adenocarcinoma as the histologic type with a mean
Gleason score of 9.36±13.14. A Spearman’s rank order
correlation was statistically significant (rs (50) = -0.423, p =
0.002).
Conclusion
A Spearman’s rank order correlation shows a
moderate negative correlation between the serum 25-
hydroxy vitamin D and Gleason score (rs (50) = -0.423, p =
0.002.Thus, serum 25-hydroxy vitamin D assay can be used
to prognosticate in patients with cancer of the prostate.
Keywords :
Serum 25-Hydroxy Vitamin D, Prostate Cancer, Gleason Score
