Authors :
Giovanni Antonio Wijanto; Agustin Iskandar; Catur Suci Sutrisnani
Volume/Issue :
Volume 8 - 2023, Issue 7 - July
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/5n7e3abc
DOI :
https://doi.org/10.5281/zenodo.8210443
Abstract :
Severe and critical cases of COVID-19 can
occur due to a cytokine storm involving many
inflammatory mediators including platelets, lymphocytes,
cytokines and chemokines. Platelets are one of the factors
that affect inflammation indirectly, while lymphocytes
will be greatly affected in the state of COVID-19 where
both can decrease due to various reasons. One of the
cytokines involved in COVID-19 is IFN-γ which can
trigger other cytokines in a cytokine storm in COVID-19
and various other conditions related to COVID-19. In
COVID-19, there is also an increase in Platelet-To-
Lymphocyte Ratio (PLR) and IFN-γ. The increase in PLR
and IFN-γ is expected to be one of the means of predicting
patient outcomes. To see the correlation between PLR,
IFN-γ, and mortality, we conducted a logistic regression
test, path analysis, and survival analysis. There were no
significant differences in IFN-γ levels, PLR, and length of
treatment between survivor and non-survivor patients. In
addition, there were no significant differences in all
characteristics of subjects with mild-moderate, severe,
and very severe severity. It can be concluded that IFN-γ
and PLR were not correlated with each other and when
combined, IFN-γ and PLR showed no difference in
prognosis obtained from survival analysis.
Keywords :
COVID-19, Interferon Gamma, Platelet-To- Lymphocyte Ratio, Mortality.
Severe and critical cases of COVID-19 can
occur due to a cytokine storm involving many
inflammatory mediators including platelets, lymphocytes,
cytokines and chemokines. Platelets are one of the factors
that affect inflammation indirectly, while lymphocytes
will be greatly affected in the state of COVID-19 where
both can decrease due to various reasons. One of the
cytokines involved in COVID-19 is IFN-γ which can
trigger other cytokines in a cytokine storm in COVID-19
and various other conditions related to COVID-19. In
COVID-19, there is also an increase in Platelet-To-
Lymphocyte Ratio (PLR) and IFN-γ. The increase in PLR
and IFN-γ is expected to be one of the means of predicting
patient outcomes. To see the correlation between PLR,
IFN-γ, and mortality, we conducted a logistic regression
test, path analysis, and survival analysis. There were no
significant differences in IFN-γ levels, PLR, and length of
treatment between survivor and non-survivor patients. In
addition, there were no significant differences in all
characteristics of subjects with mild-moderate, severe,
and very severe severity. It can be concluded that IFN-γ
and PLR were not correlated with each other and when
combined, IFN-γ and PLR showed no difference in
prognosis obtained from survival analysis.
Keywords :
COVID-19, Interferon Gamma, Platelet-To- Lymphocyte Ratio, Mortality.
