Epicardial adipose tissue (EAT) is splanchnopleuric mesoderm-derived tissue that communicates locally with coronary vessels and myocardium via paracrine and vasocrine routes. This tissue secretes pro-atherogenic and pro-inflammatory cytokines that affect cardiac function. Some studies found a significant relationship between EAT thickness and coronary artery disease (CAD). Methods: This analytical, observational study aimed to assess the relationship between EAT thickness and coronary artery stenosis lesion severity in CAD patients of RSUP HAM. EAT thickness was measured using Doppler echocardiography by a cardiologist, while the severity of coronary artery stenosis lesion was determined by SYNTAX score. Bivariate analysis and Ttest were used to analyze the difference between CAD with significant lesion and nonsignificant groups. ROC (Receiver Operating Curve) analysis was used to determine the cut-off value of EAT thickness that could predict the severity of the lesion. Results: All 79 patients (39 CAD with significant lesion and 39 nonsignificant lesion) was dominated by male (57,6% and 42,4%). Diastole and systole EAT thickness of ≥2,75 mm, and ≥5,5 mm could predict CAD diagnoses. These cut-off points also had six times higher risk of developing significant coronary artery lesion, which was described by a SYNTAX score of > 22 [each had OR of 6,000 (IK95% 1,296-27,769)] Conclusion: EAT thickness measurement using echocardiography could differentiate CAD with signifincant lesion with non-significant patients, and it also could predict the severity of coronary artery lesions in CAD patient

Keywords : Epicardial Adipose Tissue, SYNTAX, CAD.