Correlation between the Leukocyte Levels upon First Hospitalization and Clinical Outcomes in Acute Ischemic Stroke


Authors : Diayanti Tenti Lestari; Mohammad Saiful Ardhi; Mudjiani Basuki

Volume/Issue : Volume 6 - 2021, Issue 10 - October

Google Scholar : http://bitly.ws/gu88

Scribd : https://bit.ly/3CtgcAX

Background and Purpose: Based on the high mortality and morbidity rate, stroke is included as a major public health disease. The inflammatory response of stroke is mediated by the immune system. In ischemic stroke, increased expression of various cytokines and chemokines causes leukocyte infiltration into ischemic tissue. It has considered as the main mediator of the response of inflammation and endothelial destruction. Leukocytes assessment upon hospitalisation is expected to define the specific treatment of stroke patients efficiently. This study aimed to identify the correlation between leukocyte level upon hospitalized and clinical outcomes of mild and moderate acute ischemic stroke in neurologic inpatients care at Dr. Soetomo Hospital. Method: A retrospective cross-sectional method was used in this study. Sample data were collected from the stroke registry in the neurologic room at Dr. Soetomo hospital from January to March 2019. Leukocyte levels were collected upon hospitalisation and the clinical outcome of stroke. The data were assessed using the National Institutes of Health Stroke Scale (NIHSS) upon discharge. Data were analysed using SPSS version 24 with p<0.05 as a significant value. Result: From the stroke registry data, it was found that 55 subjects have fulfilled the criteria for this study. Patients with a mild deficit NIHSS clinical outcome with normal leukocyte level showed in 23 (82%) patients, while there were 5 (18%) patients who had leucocytosis. Patients with moderate deficit NIHSS clinical outcomes showed normal leukocyte values in 14 (52%) patients and as many as 13 (48%) patients showed leucocytosis. The chisquare test resulted in a significant value with p-value = 0.017 (RO: 4.27 (95% CI = 1.25-14.56)). Conclusion: There is a correlation between leukocyte values at baseline and clinical outcome of acute ischemic stroke with mild deficits and moderate deficits as assessed by the NIHSS.

Keywords : Leukocytes; Ischemic Stroke; Clinical Outcome; NIHSS; Mild and Moderate Deficits.

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