Authors : Dr. Raju Anarthe; Dr. Amit Mani; Dr. Pranjali Jagtap; Dr. Prajwal Sonawane; Dr. Shweta Vikhe

Volume/Issue : Volume 9 - 2024, Issue 9 - September

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DOI : https://doi.org/10.38124/ijisrt/IJISRT24SEP1161

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Abstract : Regenerative procedures have become a key focus in contemporary rehabilitation therapies. In dentistry, research on growth factors for bone regeneration has identified autologous growth factors as the most effective stimuli for tissue regeneration and healing. These bioactive proteins play a crucial role in wound healing. Concentrated growth factor (CGF) is a recent advancement in 2 nd generation platelet concentrates. The use of different centrifugation speeds helps to obtain a significantly dense fibrin. Also, it contains more amount of growth factors than the other platelet concentrates available.

Keywords : Growth Factors, Regeneration, Platelet-Rich Fibrin, Healing.

References :

1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. The lancet. 2005 Nov 19;366(9499):1809-20.
2. TTaba Jr M, Jin Q, Sugai JV, Giannobile WV. Current concepts in periodontal bioengineering. Orthodontics & craniofacial research. 2005 Nov;8(4):292-302.
3. TTayalia P, Mooney DJ. Controlled growth factor delivery for tissue engineering. Advanced materials. 2009 Sep 4;21(32‐33):3269-85.
4. BBosshardt DD, Sculean A. Does periodontal tissue regeneration really work?. Periodontology 2000. 2009 Oct 1;51(1).
5. GGiannotti L, Di Chiara Stanca B, Spedicato F, Nitti P, Damiano F, Demitri C, Calabriso N, Carluccio MA, Palermo A, Siculella L, Stanca E. Progress in regenerative medicine: exploring autologous platelet concentrates and their clinical applications. Genes. 2023 Aug 23;14(9):1669.
6. MMihaylova Z, Mitev V, Stanimirov P, Isaeva A, Gateva N, Ishkitiev N. Use of platelet concentrates in oral and maxillofacial surgery: an overview. Acta Odontologica Scandinavica. 2017 Jan 2;75(1):1-1.
7. MMehta M, Rai P, Shetty D. Concentrated Growth Factor: A Review. Int J Dentistry Oral Sci. 2020 Aug 31;7(8):799-803.
8. BBernardi S, Mummolo S, Tecco S, Continenza MA, Marzo G. Histological characterization of Sacco’s concentrated growth factors membrane. Int. J. Morphol. 2017 Mar 1;35(1):114-9.
9. Bornfeldt KE, Raines EW, Graves LM, Skinner MP, Krebs EG, Ross R. Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation. Annals of the New York Academy of Sciences. 1995 Sep 1;766:416-30.
10. GROMACK DT, REYES BP, MUSTOE TA. Current concepts in wound healing growth factor and macrophage interaction. Journal of Trauma and Acute Care Surgery. 1990 Dec 1;30:129-33.
11. Bolander ME. Regulation of fracture repair by growth factors. Proceedings of the Society for Experimental Biology and Medicine. 1992 Jun;200(2):165-70.
12. Pierce GF, Tarpley JE, Allman RM, Goode PS, Serdar CM, Morris B, Mustoe TA, Berg JV. Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB. The American journal of pathology. 1994 Dec;145(6):1399.
13. Tsay RC, Vo J, Burke A, Eisig SB, Lu HH, Landesberg R. Differential growth factor retention by platelet-rich plasma composites. Journal of oral and maxillofacial surgery. 2005 Apr 1;63(4):521-8.
14. Ai-Aql ZS, Alagl AS, Graves DT, Gerstenfeld LC, Einhorn TA. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. Journal of dental research. 2008 Feb;87(2):107-18.
15. Linkhart TA, Mohan S, Baylink DJ. Growth factors for bone growth and repair: IGF, TGFβ and BMP. Bone. 1996 Jul 1;19(1):S1-2.
16. Sohn DS, Moon JW, Moon KN, Cho SC, Kang PS. New bone formation in the maxillary sinus using only absorbable gelatin sponge. Journal of Oral and Maxillofacial Surgery. 2010 Jun 1;68(6):1327-33.
17. Sohn DS, Heo JU, Kwak DH, Kim DE, Kim JM, Moon JW, Lee JH, Park IS. Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone. Implant dentistry. 2011 Oct 1;20(5):389-95.
18. Sohn DS, Moon JW, Moon YS, Park JS, Jung HS. The use of concentrated growth factors (CGF) for sinus augmentation. J Oral Implant. 2009;38(1):25-38.
19. Sohn DS. The effect of concentrated growth factors on ridge augmentation. Dental Inc. 2009 Sep;20(1):34-40.
20. Sohn DS. The use of concentrated growth factors as alternative to bone substitutes for sinus augmentation. Dental Inc. 2009 Mar;2:1-7.
21. Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scarì G, Sacco L, Batani T, Rezzani R. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microscopy research and technique. 2011 Aug;74(8):772-7.
22. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2006 Mar 1;101(3):e37-44.
23. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2006 Mar 1;101(3):e45-50.
24. Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth factors. 2009 Jan 1;27(1):63-9.
25. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three‐dimensional architecture and cell composition of a Choukroun's platelet‐rich fibrin clot and membrane. Journal of periodontology. 2010 Apr;81(4):546-55.
26. Li S, Yang H, Duan Q, Bao H, Li A, Li W, Chen J, He Y. A comparative study of the effects of platelet-rich fibrin, concentrated growth factor and platelet-poor plasma on the healing of tooth extraction sockets in rabbits. BMC Oral Health. 2022 Mar 23;22(1):87.
27. Qiao J, Duan J, Zhang Y, Chu Y, Sun C. The effect of concentrated growth factors in the treatment of periodontal intrabony defects. Future science OA. 2016 Dec 1;2(4):FSO136.
28. Gökmenoğlu C, Yavuz MC, Sadik E, Çanakçi V, Kara C. Treatment of different types of bone defects with concentrated growth factor: four case reports. Int J Oral Dent Health. 2016;2:029.
29. Mirković S, Đurđević-Mirković T, Puškar T. Application of concentrated growth factors in reconstruction of bone defects after removal of large jaw cysts: the two cases report. Vojnosanitetski pregled. 2015;72(4):368-71.
30. Durmuslar MC, Balli U, Dede FÖ, Misir AF, Baris E, Kürkçü M, Kahraman SA. Histological evaluation of the effect of concentrated growth factor on bone healing. Journal of Craniofacial Surgery. 2016 Sep 1;27(6):1494-7.
31. Pirpir C, Yilmaz O, Candirli C, Balaban E. Evaluation of effectiveness of concentrated growth factor on osseointegration. International journal of implant dentistry. 2017 Dec;3(1):1-6.