Authors :
Chandra Sekhar Tripathy
Volume/Issue :
Volume 7 - 2022, Issue 5 - May
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3xvaahI
DOI :
https://doi.org/10.5281/zenodo.6658851
Abstract :
Lung cancer is a cancer that starts in the lungs
and spreads throughout the body. The lungs are two
spongy organs in the chest that take in oxygen and release
carbon dioxide as we inhale and exhale. Lung cancer is
the most common cancer that kills people around the
world. Lung cancer is most common in smokers, although
it can also strike persons who have never smoked. The
amount of time and number of cigarettes you smoke raises
your risk of lung cancer. However, physiologically the
protein CFLAR (CASP8 and FADD-like apoptosis
regulator) is found to be widely associated with lung
cancer and is also over expressed. Curcuma caesia is an
herbal plant with lots of known medicinal properties.
Curcuma caesia has 50 known phyto-compounds (PCs). In
the present investigation all the 50 PCs have been put to
in silico processes including docking analysis to find out
the PCs that best stop over-expression of the CFLAR
protein in Lung cancer. Tau-Cadinol and Delta-Cadinene
are found to be champion molecules of this plant against
Lung cancer.
Keywords :
CFLAR, Lung cancer , docking , in silico ,Curcuma caesia
Lung cancer is a cancer that starts in the lungs
and spreads throughout the body. The lungs are two
spongy organs in the chest that take in oxygen and release
carbon dioxide as we inhale and exhale. Lung cancer is
the most common cancer that kills people around the
world. Lung cancer is most common in smokers, although
it can also strike persons who have never smoked. The
amount of time and number of cigarettes you smoke raises
your risk of lung cancer. However, physiologically the
protein CFLAR (CASP8 and FADD-like apoptosis
regulator) is found to be widely associated with lung
cancer and is also over expressed. Curcuma caesia is an
herbal plant with lots of known medicinal properties.
Curcuma caesia has 50 known phyto-compounds (PCs). In
the present investigation all the 50 PCs have been put to
in silico processes including docking analysis to find out
the PCs that best stop over-expression of the CFLAR
protein in Lung cancer. Tau-Cadinol and Delta-Cadinene
are found to be champion molecules of this plant against
Lung cancer.
Keywords :
CFLAR, Lung cancer , docking , in silico ,Curcuma caesia
