Authors : Yusuf Yakub Oloriegbe; Fatimah Hassan-Hanga; Bello Abdullahi Ibrahim; Shehu Umar Abdullahi; Maimuna Orahachi Yusuf; Iragbogie Al-Mustapha Imoudu; Ismail Kalamu Musa; Lamidi Isah Audu

Volume/Issue : Volume 11 - 2026, Issue 5 - May

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Google Scholar : https://tinyurl.com/39pvwrrs

Scribd : https://tinyurl.com/stzrfmfn

DOI : https://doi.org/10.38124/ijisrt/26May524

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Abstract : Background: Staphylococcus aureus carriage is a major risk factor for invasive infections in children with sickle cell anaemia (SCA). The optimal sampling site for comprehensive carriage detection in this high-risk population remains undefined. We compared nasopharyngeal versus anterior nares sampling for S. aureus and methicillin-resistant S. aureus (MRSA) detection.  Methods: This comparative cross-sectional study enrolled 100 children with SCA (aged 1-14 years) attending two tertiary facilities in Kano, Nigeria. Paired nasopharyngeal and anterior nares swabs were collected from each participant and processed using standard microbiological methods. Using combined results from both sites as the reference standard, detection rates, concordance (Cohen's kappa), and sensitivity for each sampling method were calculated.

Keywords : Staphylococcus aureus; MRSA; Sampling Method; Nasal Carriage; Nasopharyngeal Carriage; Sickle Cell Anaemia; Paediatric; Nigeria.

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