Comparison of Concentrations of MMP2 and MMP9 in Aqueous Humor of Patients Suffering with Acute Primary Angle Closure Short Title: MMPs and acute primary angle closure


Authors : Dr Raj Kumar Gupta

Volume/Issue : Volume 7 - 2022, Issue 9 - September

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3fUSwiK

DOI : https://doi.org/10.5281/zenodo.7312298

Objective- Inflammation with neovascularization leads to elevated intraocular pressure( IOP) which is only modified risk factor for acute primary angle closure ( APAC) caused by decreased aqueous humor outflow from the anterior chamber. The present study has been planned to compare the levels of MMPs in aqueous humor of patients with APAC and aimed to analyse the molar ratio of MMPs with respect to the other MMPs. Methods- Aqueous humor samples were collected from 46 healthy control persons ( non-glaucomatous) and 52 APAC patients undergoing cataract surgery. Molar concentrations of all the MMPs were measured using multiplexed immunoassays Kit Methods. Statistical significance was assessed with Mann–Whitney U tests, and Spearman’s method was used to assess correlations with age and IOP.

Keywords : MMP2, MMP9 , Acute primary angle closure.

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