People Living with HIV/AIDS (PLWHA) benefit from Anti-Retroviral Treatment to reduce transmission and improve quality of life.  Objective This study Compares the level of Antiretroviral Medication Adherence among PLWHA in Selected Districts of Taraba State, Nigeria.  Methods Descriptive Survey was adopted using a validated questionnaire to gather information from 120 PLWHA. This followed ethical Permission from Taraba State Ministry of Health and informed consent from participants. Descriptive statistics and frequency distributions were employed in the analysis of data. Paired sample T-test for statistical significance was used to compare means of the variables. Validity and reliability of Instrument were tested with Cronbach Alpha, 0.785 It can be observed that Antiretroviral Medication adherence is generally sub-optimal against the recommended 95% adherence level. It is therefore, recommended that Strategically targeted theorygrounded HIV intervention programs will be more effective than the usual clinic-based program for the management of HIV/ AIDS.

Keywords : Education, Adherence, Predisposing, Reinforcing, Enabling