Palatal rugae duplication in complete denture prosthesis acts as an effective aid helping patient to favourably position his tongue during denture adaptation. This aids the patient in learning to speak with dentures shortly, hence improving his denture satisfaction. Covering the palatal area by denture base acrylic resin results in proprioceptive changes hence rendering most of the complete denture wearers handicapped with respect to speech and pronunciation. Although, evident importance of palatal rugae in speech production has not been proven, it has been suggested that duplicating the palatine rugae in the complete denture base facilitates speech especially the linguopalatal consonants. Aim: The present in vivo study was done to compare compliance and speech intelligibility of complete denturewearers with conventional denture & denture with modified anterior palate. Materials and Methods: The study included four phases (phase one without denture, phase two with conventional complete denture, phase three subject with complete denture having anatomic palate fabricated in PMMA and phase four with complete denture having anatomic palate fabricated in silicone). Sound samples were recorded in each phase. Fifty individuals in the age group of 55 to 70 years participated in the study. The sound samplesrecorded from each subject were assessed both quantitatively (by speech analysis software) and qualitatively (by team of speech specialist). The recorded data was analysed using a one-way ANOVA for repeated measurements and Mann-Whitney U test for Likert’s scale rating. Results: Quantitatively Pitch & intensity of phase IV as per statistical analysis showed significant difference from phase I and patients showed more compliance for phase IV dentures. Conclusion: Within the extent of this in vivo study, it can be inferred that speech intelligibility as well as compliance after denture Insertion was more in phase IV followed by phase III and phase II.