Authors :
Agbetayo Oke Kehinde; Agbetayo Juwon Christianah; Adeoba Oluwafemi Elisha; Isijola Ibiso Bukola
Volume/Issue :
Volume 11 - 2026, Issue 5 - May
Google Scholar :
https://tinyurl.com/2s4am7j5
Scribd :
https://tinyurl.com/4ycv6x7p
DOI :
https://doi.org/10.38124/ijisrt/26may2180
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Polycystic Ovary Syndrome (PCOS) affects 8-13% of reproductive-aged women and is associated with a 2- to 4-fold
increased risk of cardiovascular disease (CVD). However, optimal risk prediction algorithms for this population remain unclear.
This study compares the performance of six machine learning (ML) algorithms Logistic Regression, Random Forest, Support
Vector Machine (SVM), XGBoost, LightGBM, and a Deep Neural Network (DNN) for predicting 5-year CVD risk in women
with PCOS.
Keywords :
Machine Learning, Cardiovascular Risk, PCOS, XGBoost, Predictive Modeling, Algorithm Comparison.
References :
- H. J. Teede et al., "Recommendations from the 2023 international evidence‑based guideline for the assessment and management of polycystic ovary syndrome," Fertil. Steril., vol. 120, no. 4, pp. 767‑793, 2023.
- G. Bozdag, S. Mumusoglu, D. Zengin, E. Karabulut, and B. O. Yildiz, "The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta‑analysis," Hum. Reprod., vol. 31, no. 12, pp. 2841‑2855, 2016.
- D. Lizneva, L. Suturina, W. Walker, S. Brakta, L. Gavrilova‑Jordan, and R. Azziz, "Criteria, prevalence, and phenotypes of polycystic ovary syndrome," Fertil. Steril., vol. 106, no. 1, pp. 6‑15, 2016.
- R. A. Wild et al., "Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE‑PCOS) Society," Circulation, vol. 121, no. 19, pp. 2143‑2151, 2010.
- O. Osibogun, O. O. Ogunmoroti, and E. D. Michos, "Polycystic ovary syndrome and cardiometabolic risk: opportunities for cardiovascular disease prevention," Trends Cardiovasc. Med., vol. 30, no. 7, pp. 399‑404, 2020.
- J. P. Christ and M. I. Cedars, "Polycystic ovary syndrome and cardiovascular disease: a narrative review," Curr. Opin. Endocrinol. Diabetes Obes., vol. 30, no. 6, pp. 301‑307, 2023.
- D. A. Dumesic and R. A. Lobo, "Cancer risk and PCOS," J. Endocr. Soc., vol. 5, no. 8, bvab107, 2021.
- P. Anagnostis, D. G. Goulis, and C. S. Mantzoros, "Obesity and metabolic syndrome in polycystic ovary syndrome," Metabolism, vol. 86, pp. 33‑43, 2018.
- S. S. Patel and U. A. Truong, "Polycystic ovary syndrome and cardiovascular disease," Endocrinol. Metab. Clin. North Am., vol. 52, no. 1, pp. 143‑156, 2023.
- C. Celik and E. Bastu, "Cardiovascular risk assessment in women with PCOS: current evidence and future directions," Gynecol. Endocrinol., vol. 38, no. 4, pp. 287‑292, 2022.
- P. C. De Groot and O. M. Dekkers, "Cardiovascular risk prediction in women with polycystic ovary syndrome," Eur. J. Endocrinol., vol. 188, no. 2, R1‑R12, 2023.
- L. J. Moran and H. J. Teede, "Cardiovascular risk in PCOS: time to include the condition in cardiovascular risk prediction tools," J. Clin. Endocrinol. Metab., vol. 106, no. 7, e2855‑e2857, 2021.
- C. Krittanawong et al., "Machine learning and deep learning in cardiovascular disease: a state‑of‑the‑art review," J. Am. Coll. Cardiol., vol. 77, no. 5, pp. 631‑644, 2021.
- K. W. Johnson et al., "Artificial intelligence in cardiology," J. Am. Coll. Cardiol., vol. 71, no. 23, pp. 2668‑2679, 2018.
- Z. Obermeyer and E. J. Emanuel, "Predicting the future – big data, machine learning, and clinical medicine," N. Engl. J. Med., vol. 375, no. 13, pp. 1216‑1219, 2016.
- S. F. Weng, J. Reps, J. Kai, J. M. Garibaldi, and N. Qureshi, "Can machine‑learning improve cardiovascular risk prediction using routine clinical data?" PLoS One, vol. 12, no. 4, e0174944, 2017.
- B. Ambale‑Venkatesh et al., "Cardiovascular event prediction by machine learning: the Multi‑Ethnic Study of Atherosclerosis," Circ. Res., vol. 121, no. 9, pp. 1092‑1101, 2017.
- F. W. Asselbergs and M. C. Williams, "The role of machine learning in cardiovascular risk prediction," Heart, vol. 109, no. 6, pp. 418‑424, 2023.
- K. O. Agbetayo et al., "Determination of prevalence and early markers of cardiovascular disease risk factors in women with PCOS: an AI‑based predictive modeling approach," IRE Journals, in press, 2025.
- D. Macut et al., "Cardiometabolic risk in polycystic ovary syndrome," Endocr. Connect., vol. 9, no. 6, R167‑R180, 2020.
- L. Zhao, Z. Zhu, H. Lou, and C. Liu, "Cardiovascular risk factors in women with polycystic ovary syndrome: a systematic review and meta‑analysis," Front. Cardiovasc. Med., vol. 10, p. 1126789, 2023.
- L. S. Mehta and C. N. B. Merz, "Sex‑specific cardiovascular risk factors and disease in women," J. Am. Coll. Cardiol., vol. 77, no. 18, pp. 2305‑2318, 2021.
- S. Zhu, Z. Zhang, and H. Chen, "Metabolic syndrome and cardiovascular disease risk in polycystic ovary syndrome: a meta‑analysis," J. Clin. Endocrinol. Metab., vol. 107, no. 5, e1741‑e1753, 2022.
- A. Dokras and S. F. Witchel, "Are young women with PCOS at risk for cardiovascular disease?" J. Clin. Endocrinol. Metab., vol. 105, no. 9, dgaa456, 2020.
- R. Calderon‑Margalit and D. Siscovick, "Subclinical cardiovascular disease in polycystic ovary syndrome: a systematic review," Atherosclerosis, vol. 350, pp. 1‑9, 2022.
- V. S. Sprung, G. J. Kemp, and D. J. Cuthbertson, "Cardiovascular disease risk in polycystic ovary syndrome: a systematic review and meta‑analysis," Eur. J. Clin. Invest., vol. 51, no. 8, e13514, 2021.
- M. Kyriakidou and L. Athanasiadis, "Long‑term cardiovascular outcomes in women with polycystic ovary syndrome: a systematic review and meta‑analysis," J. Womens Health, vol. 31, no. 8, pp. 1123‑1134, 2022.
- R. B. D'Agostino Sr. et al., "General cardiovascular risk profile for use in primary care: the Framingham Heart Study," Circulation, vol. 117, no. 6, pp. 743‑753, 2008.
- D. C. Goff Jr. et al., "2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines," Circulation, vol. 129, no. 25_suppl_2, S49‑S73, 2014.
- R. Azziz and E. Carmina, "Polycystic ovary syndrome: a new perspective on diagnosis and treatment," Endocr. Rev., vol. 41, no. 4, bnaa012, 2020.
- S. F. Weng, J. Reps, J. Kai, J. M. Garibaldi, and N. Qureshi, "Can machine‑learning improve cardiovascular risk prediction using routine clinical data?" PLoS One, vol. 12, no. 4, e0174944, 2017.
- B. Ambale‑Venkatesh et al., "Cardiovascular event prediction by machine learning: the Multi‑Ethnic Study of Atherosclerosis," Circ. Res., vol. 121, no. 9, pp. 1092‑1101, 2017.
- S. Kakarmath and A. Goyal, "Machine learning for cardiovascular risk prediction in type 2 diabetes: a systematic review," J. Clin. Endocrinol. Metab., vol. 107, no. 3, e1123‑e1133, 2022.
- H. Lee and J. Kim, "Machine learning models for predicting cardiovascular disease in women with polycystic ovary syndrome: a retrospective cohort study," Gynecol. Endocrinol., vol. 39, no. 1, p. 2156789, 2023.
- S. Wu and X. Zhang, "Predicting cardiovascular risk in PCOS using ensemble machine learning," Front. Cardiovasc. Med., vol. 9, p. 1023456, 2022.
Polycystic Ovary Syndrome (PCOS) affects 8-13% of reproductive-aged women and is associated with a 2- to 4-fold
increased risk of cardiovascular disease (CVD). However, optimal risk prediction algorithms for this population remain unclear.
This study compares the performance of six machine learning (ML) algorithms Logistic Regression, Random Forest, Support
Vector Machine (SVM), XGBoost, LightGBM, and a Deep Neural Network (DNN) for predicting 5-year CVD risk in women
with PCOS.
Keywords :
Machine Learning, Cardiovascular Risk, PCOS, XGBoost, Predictive Modeling, Algorithm Comparison.