Hepatocellular carcinoma (HCC) is the sixth common type of cancer worldwide. Besides the involvement of HCV, HBV and Alcohol intake various non-pathogenic viruses like Anelloviruses and SEN virus are also reported from HCC and various other diseases. The human gyro virus, inducing an immunosuppressive disorder in chickens however investigated in case of various diseased and normal individuals. Methodology: The current meta-analysis study collected the data of three researchers who analyzed the presence of SEN viruses, Anelloviruses and human gyro viruses. Statistical analysis were performed and p<0.005 were define as statistically significant. Results: Evaluation of total 42 normal individual showed the absence of SEN viruses, Anelloviruses and human gyro viruses. A total 62.8% (22/35) prevalence rate of SENV among Dengue infected patients however HCV, HBV, Anelloviruses and human gyro viruses were not found. Among Hepatitis B infected individuals 13.8% (9/65) were found co-infected with SENV and 33.8% (22/65) have Anelloviruses infections however infection with other viruses like HCV and human gyro viruses were not observed. Among HCC infected individuals 5% were positive for HBV and 82.5% for HCV however the other non-pathogenic hepatotropic viruses like SEN, Anelloviruses and human gyro viruses were not present. Conclusion: The current study concluded that the presence of any infection/disease flatten the curve for the co-infection of various non-pathogenic hepatotropic viruses like SENV and AVs however the human gyro viruses is independent of any infection.

Keywords : Hepatocellular Carcinoma, Hepatitis C Virus, Hepatitis B Virus, Human Gyro Virus