- Collagens are a family of extracellular matrix
that helps tissues and organs retain their structural
integrity. In mammals, it accounts for about 30% of all
proteins and forms a building block of body structure. It
is predominantly present in the skin, blood vessels,
tendons, cartilages, bone, teeth, and cornea. It plays an
important role in the healing of wounds and fractures.
Excessive collagen in the body leads to fibrosis of various
organs. There are certain diseases related to collagen such
as Ehlers- danlos syndrome, Osteogenesis imperfecta,
Alport syndrome, Scurvy, Oral submucous fibrosis,
Marfan’s syndrome. Collagen's function in health and
disease is discussed in this review article
Keywords : Collagen; Extracellular Matrix; Structure; Fibroblast.