Wheezing in childhood is not a single disorder and different wheezing associated respiratory illnesses have been recently described. Not all children who wheeze in early infancy will continue to wheeze into childhood andadulthood.  Aims And Objectives This study aims to determine the clinical profile and risk factors of wheezing in children under five years of age in a tertiary care hospital in eastern India.  Methodology All children less than 5 years of age diagnosed to have wheeze attending the pediatric department of HiTech medical college and hospital, Bhubaneswar were evaluated by collecting baseline data of the child, clinical evaluation and investigation. Type of study- Cross Sectional Study Parents or legal guardians of infants who gave consent for the study were interviewed and asked standardized questionnaires about demographic characteristics as well as about wheezing and its potential risk factors. Statistical Analysis- The data are collected and entered into excel sheets , relative statistical tests like percentage , graphs and tables are done.  Result Wheezing in children under five years of age has a heterogeneous group of risk factors and clinical diagnosis. In our study Episodic viral triggered wheeze was the commonest cause of wheezing (22.30%) followed by acute bronchiolitis (20.76%) and bronchopneumonia (16.92%) and moderate bronchial asthma (13.84%). Wheezing in children less than five years of age was independently associated with male child, family history of atopy, antenatal infection, preterm delivery, NICU admission and overcrowding in the family.  Conclusion The study of risk factors of wheezing in less than five years of age is important to help physicians identify young children at high risk of developing asthma and to improve public health prevention strategies in order to reduce the morbidity of wheezing in childhood

Keywords : Infant, Wheezing, Asthma, Risk Factors